伊朗社区获得性肺炎儿科样本中的耐大环内酯肺炎支原体

IF 0.5 4区 医学 Q4 MICROBIOLOGY Jundishapur Journal of Microbiology Pub Date : 2023-12-01 DOI:10.5812/jjm-137413
Seyyed Alireza Fahimzad, A. Karimi, S. Nadji, Najmeh Tavousi, M. Abedini, Roghayeh Amini, A. Hosseininasab, Fatemeh Hosseininasab, K. Ghadiri, Roya Chegene Lorestani Sha Masoomshahi, M. Aelami, B. Abdinia, H. Hashemian, M. S. Rezai, Anahita Sanaei Dashti, Z. Pourmoghaddas
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引用次数: 0

摘要

背景:据我们所知,伊朗儿童的大环内酯耐药肺炎支原体(MRM)患病率尚未调查。目的:本研究旨在评估伊朗社区获得性肺炎(CAP)儿童MRM的患病率。方法:选取10所儿童医院收治的222例3 ~ 15岁CAP患儿为研究对象。采用聚合酶链反应(PCR)法检测支原体。根据美国传染病学会(IDSA)指南评估CAP的严重程度。c反应蛋白(CRP)水平也通过颗粒增强浊度免疫分析法测定。此外,还记录了CAP患儿的胸部x光片,并将其发送给放射科医生进行进一步评估。结果:21例确诊为CAP的患儿(9.4%)同时存在肺炎支原体感染,其中17例(77.27%)A2063G转化阳性,且大环内酯类药物耐药水平较高。MRM肺炎患儿的CAP严重程度(P≥0.99)、CRP水平(0.07)、胸片变化(P = 0.08)与大环内酯敏感肺炎支原体患儿无显著差异。结论:伊朗儿童高水平MRM肺炎患病率高,与其他亚洲国家相似。然而,这种类型的支原体感染与CAP的严重程度无关,对患者的胸部x光片(CXR)变化或CRP水平没有显著影响。
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Macrolide-resistant Mycoplasma pneumoniae in an Iranian Pediatric Sample with Community-Acquired Pneumonia
Background: To the best of our knowledge, the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRM) in Iranian children has not been investigated. Objectives: The present study aimed to evaluate the prevalence of MRM in Iranian children with community-acquired pneumonia (CAP). Methods: A total of 222 children with CAP, aged 3 - 15 years, who were hospitalized in 10 different children's hospitals, were enrolled in this study. Mycoplasmas were detected using the polymerase chain reaction (PCR) assay. The severity of CAP was evaluated according to the Infectious Diseases Society of America (IDSA) guidelines. The level of C-reactive protein (CRP) was also measured by the particle-enhanced turbidimetric immunoassay. Additionally, the chest X-rays of children with CAP were recorded and sent to a radiologist for further evaluation. Results: Twenty-one children (9.4%) diagnosed with CAP also had M. pneumoniae infection, 17 (77.27%) of whom were positive for A2063G transition and high-level macrolide resistance. The severity of CAP (P ≥ 0.99), CRP level (0.07), and chest X-ray changes (P = 0.08) were not significantly different between children with MRM pneumonia and those with macrolide-susceptible M. pneumoniae. Conclusions: The prevalence of high-level MRM pneumonia in children is high in Iran, similar to other Asian countries. However, this type of Mycoplasma infection was not associated with the severity of CAP and did not have significant effects on chest X-ray (CXR) changes or the CRP level in the patients.
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Jundishapur Journal of Microbiology, (JJM) is the official scientific Monthly publication of Ahvaz Jundishapur University of Medical Sciences. JJM is dedicated to the publication of manuscripts on topics concerning all aspects of microbiology. The topics include medical, veterinary and environmental microbiology, molecular investigations and infectious diseases. Aspects of immunology and epidemiology of infectious diseases are also considered.
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