{"title":"一例 MET 14 号外显子跳越突变阳性的肺肉瘤样癌伴胰腺转移的罕见病例","authors":"Tatsuya Hayashi , Shinji Otani , Riko Kitazawa , Takashi Ueki , Takao Ishimura , Takahito Sugihara , Fumiya Ogura , Yousuke Kiriyama , Yu Mori , Nobuhiko Sakao , Yoshifumi Sano , Hironori Izutani","doi":"10.1016/j.rmcr.2023.101956","DOIUrl":null,"url":null,"abstract":"<div><p>Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma with a MET exon 14 skipping mutation. A biopsy of the pancreatic lesion subsequently revealed pancreatic metastasis. A MET exon 14 skipping mutation was confirmed, and the patient was treated with a MET tyrosine kinase inhibitor and maintained a complete response for 2 years. Lung sarcomatoid carcinoma rarely metastasizes to the pancreas and can be adequately treated with a MET tyrosine kinase inhibitor.</p></div>","PeriodicalId":51565,"journal":{"name":"Respiratory Medicine Case Reports","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221300712300151X/pdfft?md5=268fca279106914f2a74795759a36553&pid=1-s2.0-S221300712300151X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A rare case of MET exon 14 skipping mutation-positive pulmonary sarcomatoid carcinoma with pancreatic metastasis\",\"authors\":\"Tatsuya Hayashi , Shinji Otani , Riko Kitazawa , Takashi Ueki , Takao Ishimura , Takahito Sugihara , Fumiya Ogura , Yousuke Kiriyama , Yu Mori , Nobuhiko Sakao , Yoshifumi Sano , Hironori Izutani\",\"doi\":\"10.1016/j.rmcr.2023.101956\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma with a MET exon 14 skipping mutation. A biopsy of the pancreatic lesion subsequently revealed pancreatic metastasis. A MET exon 14 skipping mutation was confirmed, and the patient was treated with a MET tyrosine kinase inhibitor and maintained a complete response for 2 years. Lung sarcomatoid carcinoma rarely metastasizes to the pancreas and can be adequately treated with a MET tyrosine kinase inhibitor.</p></div>\",\"PeriodicalId\":51565,\"journal\":{\"name\":\"Respiratory Medicine Case Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S221300712300151X/pdfft?md5=268fca279106914f2a74795759a36553&pid=1-s2.0-S221300712300151X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiratory Medicine Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221300712300151X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory Medicine Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221300712300151X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
摘要
肺肉瘤样癌是一种罕见肿瘤。我们报告了一例罕见的胰腺转移病例，患者是一名 76 岁的男性，患有肺肉瘤样癌。患者接受了右上肺叶切除术，被诊断为肺肉瘤样癌，并伴有 MET 第 14 号外显子跳越突变。随后进行的胰腺病灶活检发现了胰腺转移。患者接受了 MET 酪氨酸激酶抑制剂治疗，并在两年内保持了完全应答。肺肉瘤样癌很少转移到胰腺，使用MET酪氨酸激酶抑制剂就能得到充分治疗。
A rare case of MET exon 14 skipping mutation-positive pulmonary sarcomatoid carcinoma with pancreatic metastasis
Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma with a MET exon 14 skipping mutation. A biopsy of the pancreatic lesion subsequently revealed pancreatic metastasis. A MET exon 14 skipping mutation was confirmed, and the patient was treated with a MET tyrosine kinase inhibitor and maintained a complete response for 2 years. Lung sarcomatoid carcinoma rarely metastasizes to the pancreas and can be adequately treated with a MET tyrosine kinase inhibitor.
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