韩国癌症患者非医疗使用阿片类处方药的比例

S. Go, Jung Hye Kwon, Sung Woo Park, Gyeong-Won Lee, Jung Hun Kang, Eduardo Bruera
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A detailed review of medical charts was carried out, focusing on patients who had been prescribed opioids for over 60 days beyond a 12-month period following the completion of their cancer treatment (long-term PO users). Results Out of the 5,587 patients who were prescribed PO and followed up for at least 12 months, 13 cases of NMOU were identified, representing 0.23% of the patient population. Among the 204 long-term PO users, the rate was 6.37% (13/204). The most commonly misused opioids were oxycodone and fentanyl. For the group confirmed to have NMOU, the median duration of prescription was 1,327 days in total. Of the 13 patients diagnosed with NMOU, 9 reported withdrawal symptoms, 3 exhibited craving behavior for opioids, and 1 experienced both symptoms. Conclusion This study found that 0.23% of cancer patients who had been prescribed opioids in Korea demonstrated NMOU. 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摘要

目的对韩国接受处方阿片类药物(PO)的癌症患者的非医疗阿片类药物使用(NMOU)的患病率进行了有限的研究。本研究旨在确定在韩国开过阿片类药物的癌症患者中NMOU的潜在比例。方法对2009年1月至2019年12月期间接受癌症相关治疗的14728例患者进行回顾性队列分析,使用韩国一家三级医院电子收集的数据。收集了有关阿片类药物使用类型和持续时间的信息。对医疗图表进行了详细审查,重点是在癌症治疗完成后12个月期间服用阿片类药物超过60天的患者(长期PO使用者)。结果在5587例患者中,处方PO并随访至少12个月,确定了13例NMOU,占患者总数的0.23%。204名长期PO用户中,使用率为6.37%(13/204)。最常被滥用的阿片类药物是羟考酮和芬太尼。对于确认患有NMOU的组,处方的中位持续时间为1,327天。在13例诊断为NMOU的患者中,9例报告有戒断症状,3例表现出对阿片类药物的渴望行为,1例同时出现两种症状。结论本研究发现,韩国0.23%的使用阿片类药物的癌症患者出现了NMOU。尽管这一比例相对较低,但仍有必要进行仔细监测,以尽量减少这一人群中NMOU的风险,特别是在长期使用PO的人群中。
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Proportion of Non-Medical Opioid Use of Prescription Opioids among Cancer Patients in Korea
Purpose Limited research has been conducted on the prevalence of non-medical opioid use (NMOU) in Korean cancer patients who have received prescription opioids (PO). This study aimed to identify the potential proportion of NMOU in cancer patients who had been prescribed opioids in Korea. Methods A retrospective cohort analysis was conducted on 14,728 patients who underwent cancer-related treatment between January 2009 and December 2019, using electronically collected data from a tertiary hospital in Korea. Information regarding the type and duration of opioid use was gathered. A detailed review of medical charts was carried out, focusing on patients who had been prescribed opioids for over 60 days beyond a 12-month period following the completion of their cancer treatment (long-term PO users). Results Out of the 5,587 patients who were prescribed PO and followed up for at least 12 months, 13 cases of NMOU were identified, representing 0.23% of the patient population. Among the 204 long-term PO users, the rate was 6.37% (13/204). The most commonly misused opioids were oxycodone and fentanyl. For the group confirmed to have NMOU, the median duration of prescription was 1,327 days in total. Of the 13 patients diagnosed with NMOU, 9 reported withdrawal symptoms, 3 exhibited craving behavior for opioids, and 1 experienced both symptoms. Conclusion This study found that 0.23% of cancer patients who had been prescribed opioids in Korea demonstrated NMOU. Despite this relatively low rate, careful monitoring is necessary to minimize the risk of NMOU in this population, especially among long-term PO users.
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