AHR 和色氨酸代谢:免疫调节的协作动态

IF 5 3区 医学 Q1 GENETICS & HEREDITY Genes and immunity Pub Date : 2023-12-16 DOI:10.1038/s41435-023-00235-6
Jingjing Zhu, Benoit J. Van den Eynde
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引用次数: 0

摘要

深刻理解免疫系统内部错综复杂的调节机制对于驾驭复杂的癌症和免疫疗法至关重要。这篇评论文章深入探讨了色氨酸代谢、吲哚胺 2,3-二氧合酶 1 (IDO1) 和色氨酸二氧合酶 (TDO) 以及芳基烃受体 (AHR) 之间错综复杂的相互作用。这些元素在形成免疫反应方面发挥着关键作用,尤其是在晚期癌症中,它们的过度表达与预后不良和免疫抑制有关[1]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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AHR and tryptophan metabolism: a collaborative dynamics of immune regulation
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来源期刊
Genes and immunity
Genes and immunity 医学-免疫学
CiteScore
8.90
自引率
4.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Genes & Immunity emphasizes studies investigating how genetic, genomic and functional variations affect immune cells and the immune system, and associated processes in the regulation of health and disease. It further highlights articles on the transcriptional and posttranslational control of gene products involved in signaling pathways regulating immune cells, and protective and destructive immune responses.
期刊最新文献
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