Alexandra Valencakova, Beata Kiselova-Bilekova, Maria Figurova, Slavomir Hornak, Lubica Hornakova
{"title":"患有乳腺肿瘤的狗体内的肿瘤标记物","authors":"Alexandra Valencakova, Beata Kiselova-Bilekova, Maria Figurova, Slavomir Hornak, Lubica Hornakova","doi":"10.2478/acve-2023-0036","DOIUrl":null,"url":null,"abstract":"The aim of this study was to determine and compare values of carcinoembryonic antigen (CEA) and cancer antigen (CA 15-3) in 50 bitches with mammary tumors and 150 clinically healthy dogs. A modified procedure was used to determine the CEA and CA 15-3 markers with the human kits using the radioimmunoassay method (RIA). Samples collected from extirpated tumors of mammary glands were histologically processed and classified as per WHO guidelines. The mean values of the carcinoembryonic antigen markers ± SD were as follows: control group 0.89 ± 0.79, group with mammary gland tumor 1.53 ± 1.15. The values of cancer antigen markers CA 15-3 ± SD were: 1.52 ± 0.66 and 2.87 ± 1.11, respectively. The statistical significance for the carcinoembryonic antigen marker between groups was P < 0.0001. The cancer antigen CA 15-3 values between groups were also statistically significant with P < 0.0001. The results of the present study show that there are significant differences in both antigens between the control group and groups with mammary gland tumor in dogs.","PeriodicalId":7379,"journal":{"name":"Acta Veterinaria","volume":"268 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tumor Markers in Dogs with Mammary Gland Tumors\",\"authors\":\"Alexandra Valencakova, Beata Kiselova-Bilekova, Maria Figurova, Slavomir Hornak, Lubica Hornakova\",\"doi\":\"10.2478/acve-2023-0036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this study was to determine and compare values of carcinoembryonic antigen (CEA) and cancer antigen (CA 15-3) in 50 bitches with mammary tumors and 150 clinically healthy dogs. A modified procedure was used to determine the CEA and CA 15-3 markers with the human kits using the radioimmunoassay method (RIA). Samples collected from extirpated tumors of mammary glands were histologically processed and classified as per WHO guidelines. The mean values of the carcinoembryonic antigen markers ± SD were as follows: control group 0.89 ± 0.79, group with mammary gland tumor 1.53 ± 1.15. The values of cancer antigen markers CA 15-3 ± SD were: 1.52 ± 0.66 and 2.87 ± 1.11, respectively. The statistical significance for the carcinoembryonic antigen marker between groups was P < 0.0001. The cancer antigen CA 15-3 values between groups were also statistically significant with P < 0.0001. The results of the present study show that there are significant differences in both antigens between the control group and groups with mammary gland tumor in dogs.\",\"PeriodicalId\":7379,\"journal\":{\"name\":\"Acta Veterinaria\",\"volume\":\"268 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Veterinaria\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/acve-2023-0036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Veterinaria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/acve-2023-0036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
本研究的目的是测定并比较 50 只患有乳腺肿瘤的母犬和 150 只临床健康犬的癌胚抗原 (CEA) 和癌抗原 (CA 15-3) 值。使用改良程序，采用放射免疫分析法（RIA）用人用试剂盒测定癌胚抗原（CEA）和癌抗原（CA 15-3）标记物。从切除的乳腺肿瘤中采集的样本经组织学处理后，按照世界卫生组织的指南进行分类。癌胚抗原标记物的平均值（± SD）如下：对照组 0.89 ± 0.79，乳腺肿瘤组 1.53 ± 1.15。癌症抗原标记物 CA 15-3 的值（± SD）为：对照组 0.89 ± 0.79，乳腺肿瘤组 1.53 ± 1.15：分别为（1.52 ± 0.66）和（2.87 ± 1.11）。组间癌胚抗原标志物的统计学意义为 P < 0.0001。组间癌抗原 CA 15-3 值的统计学意义也是 P < 0.0001。本研究结果表明，对照组和患乳腺肿瘤组之间的两种抗原均存在显著差异。
The aim of this study was to determine and compare values of carcinoembryonic antigen (CEA) and cancer antigen (CA 15-3) in 50 bitches with mammary tumors and 150 clinically healthy dogs. A modified procedure was used to determine the CEA and CA 15-3 markers with the human kits using the radioimmunoassay method (RIA). Samples collected from extirpated tumors of mammary glands were histologically processed and classified as per WHO guidelines. The mean values of the carcinoembryonic antigen markers ± SD were as follows: control group 0.89 ± 0.79, group with mammary gland tumor 1.53 ± 1.15. The values of cancer antigen markers CA 15-3 ± SD were: 1.52 ± 0.66 and 2.87 ± 1.11, respectively. The statistical significance for the carcinoembryonic antigen marker between groups was P < 0.0001. The cancer antigen CA 15-3 values between groups were also statistically significant with P < 0.0001. The results of the present study show that there are significant differences in both antigens between the control group and groups with mammary gland tumor in dogs.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
