YKL-40 作为各种炎症性疾病的生物标记物：综述

IF 3.8 3区医学 Q1 MEDICAL LABORATORY TECHNOLOGY Biochemia Medica Pub Date : 2023-12-19 DOI:10.11613/bm.2024.010502

Nina Blazevic, Nina Blazevic, Dunja Rogic, Stipe Pelajic, Marijana Miler, Goran Glavcic, Valentina Ratkajec, Nikolina Vrkljan, Dejan Bakula, Davor Hrabar, Tajana Pavic

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引用次数: 0

摘要

亮点YKL-40是诊断和预测炎症性疾病的生物标记物YKL-40浓度随年龄增长而增加，在健康人群中也有变化YKL-40在胰腺/肝脏疾病、关节炎、支气管炎和败血症中的作用令人信服YKL-40在心血管/神经/肾脏疾病、糖尿病和哮喘中的作用值得商榷未来需要开展更大规模的研究，并制定YKL-40的年龄分层参考区间。

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YKL-40 as a biomarker in various inflammatory diseases: A review

Highlights YKL-40 is a biomarker for inflammatory diseases’ diagnosis and prediction YKL-40 concentration increases with age and has variations in healthy population YKL-40 is convincing in pancreatic/liver disease, arthritis, bronchitis, and sepsis YKL-40 is debatable in cardiovascular/neurological/renal disease, diabetes, asthma Future larger studies and age-stratified reference intervals of YKL-40 are needed

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来源期刊

Biochemia Medica 医学-医学实验技术

CiteScore

5.50

自引率

3.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).