酸枣仁糖浆在治疗对标准剂量第二代 H1 抗组胺药耐药的慢性自发性荨麻疹中的附加作用:双盲随机临床试验。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2023-11-01 DOI:10.30476/IJMS.2023.95531.2690
Hamid Zare, Seyed Hesamedin Nabavizdeh, Amir Mohamad Jaladat, Mohamad Mehdi Zarshenas, Mozhgan Moghtaderi, Atefeh Basirat, Nahid Nasri
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引用次数: 0

摘要

背景:尽管抗组胺药是慢性自发性荨麻疹(CSU)的一线治疗方法,但50%的患者对标准剂量无效。本研究评估了酸枣仁糖浆与抗组胺药联合使用对CSU患者的疗效:这项双盲随机临床试验于 2019 年 12 月至 2020 年 12 月在设拉子进行。64名患有荨麻疹至少6周且对常规治疗无效的CSU患者被纳入研究。他们被随机分配到干预组和对照组。在为期四周的时间里,干预组每天两次服用 7.5 毫升酸枣仁糖浆,对照组每天两次服用 7.5 毫升单味酸枣仁糖浆。两组每晚均服用西替利嗪 10 毫克。连续四周,每周前后使用荨麻疹活动评分(UAS)和CU-Q2oL问卷评估荨麻疹状态和睡眠质量。数据使用 SPSS 软件 18 版进行分析:干预前,两组 UAS 平均值(P=0.490)和睡眠质量(P=0.423)差异无统计学意义。在随访期间,干预组的 UAS 显著降低(P=0.001)。此外,这一差异在第 28 天也很明显(P=0.046)。随访期间,两组的睡眠质量均有明显改善,干预组的改善更为显著:试验注册号:IRCT20190304042916N1。
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The Added-on of Ziziphus jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial.

Background: Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don't respond to standard doses. In this study, the effectiveness of Ziziphus jujube fruit syrup in combination with antihistamines was assessed in patients with CSU.

Methods: This double-blind randomized clinical trial was conducted in Shiraz between December 2019 and December 2020. 64 patients with CSU who had experienced hives for at least six weeks and did not respond to the usual treatments were enrolled in the study. They were randomly assigned to intervention and control groups using permuted block random allocation. For four weeks, the intervention group received 7.5 mL Ziziphus jujube syrup twice a day, while the control group received 7.5 mL simple jujube syrup twice a day. Both groups received cetirizine 10 mg every night. Urticaria activity score (UAS) and CU-Q2oL questionnaires were used to assess urticaria state and sleep quality before and after each week for four consecutive weeks. Data were analyzed using SPSS software version 18, and P<0.05 was considered statistically significant.

Results: Before the intervention, there was no statistically significant difference between the two groups' mean of UAS (P=0.490) and sleep quality (P=0.423). During the follow-up, UAS in the intervention group was significantly lower (P=0.001). Moreover, this difference was significant on the day 28 (P=0.046). During the follow-up, the quality of sleep in both groups improved significantly, and this improvement was more significant in the intervention group.

Conclusion: Ziziphus jujube syrup could be an effective adjuvant treatment for CSU.Trial Registration Number: IRCT20190304042916N1.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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