Monika Gogolewska, Jacek Kabziński, Ireneusz Majsterek
{"title":"细胞色素 P450 和芳胺 N-乙酰转移酶基因多态性与波兰人头颈癌发病率的关系。","authors":"Monika Gogolewska, Jacek Kabziński, Ireneusz Majsterek","doi":"10.13075/ijomeh.1896.02070","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.</p><p><strong>Material and methods: </strong>In group of 280 patients with HNC, the occurrence of polymorphic variants in <i>NAT1</i>(rs72554606), <i>NAT2</i>(rs1799930), <i>CYP1A</i>(rs1799814), <i>CYP2D</i>(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.</p><p><strong>Results: </strong>The results indicated an increased risk of HNC in <i>NAT1</i> polymorphisms in the<i> GC</i> genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and <i>NAT2</i> polymorphism in the<i> GA</i> genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the <i>CYP1A</i> polymorphism the <i>GT</i> genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the <i>TT</i> genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of <i>GA-GC</i> polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in <i>NAT2-NAT1</i> genes increases the risk of HNC. Risk-reducing effect in the polymorphism <i>GG-GT</i> (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), <i>GG-TT</i> (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), <i>GA-TT</i> (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), <i>AA-GT</i> (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in <i>NAT2-CYP1A</i> genes. In the <i>CYP2D-CYP1A</i> genes in the polymorphisms <i>CT-CC</i> (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), <i>TT-GG</i> (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), <i>TT-GC</i> (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), <i>TT-CC</i> (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).</p><p><strong>Conclusions: </strong>The<i> CYP1A</i> polymorphism shows a protective association with HNC. On the other hand, <i>NAT2</i>, <i>NAT1</i> polymorphism influence the susceptibility to developing HNC. The coexistence of the <i>NAT2-NAT1</i> genotypes increases the risk of HNC. In contrast,<i> NAT1-CYP1A</i> and <i>CYP1A-CYP2D</i> reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 6","pages":"812-824"},"PeriodicalIF":1.4000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743347/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population.\",\"authors\":\"Monika Gogolewska, Jacek Kabziński, Ireneusz Majsterek\",\"doi\":\"10.13075/ijomeh.1896.02070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.</p><p><strong>Material and methods: </strong>In group of 280 patients with HNC, the occurrence of polymorphic variants in <i>NAT1</i>(rs72554606), <i>NAT2</i>(rs1799930), <i>CYP1A</i>(rs1799814), <i>CYP2D</i>(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.</p><p><strong>Results: </strong>The results indicated an increased risk of HNC in <i>NAT1</i> polymorphisms in the<i> GC</i> genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and <i>NAT2</i> polymorphism in the<i> GA</i> genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the <i>CYP1A</i> polymorphism the <i>GT</i> genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the <i>TT</i> genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of <i>GA-GC</i> polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in <i>NAT2-NAT1</i> genes increases the risk of HNC. Risk-reducing effect in the polymorphism <i>GG-GT</i> (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), <i>GG-TT</i> (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), <i>GA-TT</i> (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), <i>AA-GT</i> (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in <i>NAT2-CYP1A</i> genes. In the <i>CYP2D-CYP1A</i> genes in the polymorphisms <i>CT-CC</i> (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), <i>TT-GG</i> (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), <i>TT-GC</i> (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), <i>TT-CC</i> (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).</p><p><strong>Conclusions: </strong>The<i> CYP1A</i> polymorphism shows a protective association with HNC. On the other hand, <i>NAT2</i>, <i>NAT1</i> polymorphism influence the susceptibility to developing HNC. The coexistence of the <i>NAT2-NAT1</i> genotypes increases the risk of HNC. In contrast,<i> NAT1-CYP1A</i> and <i>CYP1A-CYP2D</i> reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.</p>\",\"PeriodicalId\":14173,\"journal\":{\"name\":\"International journal of occupational medicine and environmental health\",\"volume\":\"36 6\",\"pages\":\"812-824\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743347/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of occupational medicine and environmental health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.13075/ijomeh.1896.02070\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of occupational medicine and environmental health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.13075/ijomeh.1896.02070","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population.
Objectives: Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.
Material and methods: In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.
Results: The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).
Conclusions: The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.
期刊介绍：
The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.
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