纤毛在斑马鱼器官形成过程中的作用

IF 4.5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Open Biology Pub Date : 2023-12-01 Epub Date: 2023-12-13 DOI:10.1098/rsob.230228
Junjun Liu, Haibo Xie, Mengfan Wu, Yidan Hu, Yunsi Kang
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引用次数: 0

摘要

纤毛是从真核细胞表面伸出的毛发状细胞器,几乎存在于所有人类细胞的表面。纤毛在信号转导、器官发育和组织稳态中起着至关重要的作用。纤毛结构和功能异常可导致一组人类疾病,即纤毛疾病。目前,斑马鱼是研究纤毛功能和纤毛疾病的理想模型,因为与人类相比,斑马鱼的纤毛结构和功能相对保守。在这篇综述中,我们将总结存在于斑马鱼胚胎和成体中的不同类型的纤毛,并概述使用斑马鱼作为脊椎动物模型进行纤毛研究的优势。我们将根据最近的研究,特别关注纤毛在斑马鱼器官形成过程中的作用。此外,我们还将强调斑马鱼纤毛研究的未来前景。
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The role of cilia during organogenesis in zebrafish.

Cilia are hair-like organelles that protrude from the surface of eukaryotic cells and are present on the surface of nearly all human cells. Cilia play a crucial role in signal transduction, organ development and tissue homeostasis. Abnormalities in the structure and function of cilia can lead to a group of human diseases known as ciliopathies. Currently, zebrafish serves as an ideal model for studying ciliary function and ciliopathies due to its relatively conserved structure and function of cilia compared to humans. In this review, we will summarize the different types of cilia that present in embryonic and adult zebrafish, and provide an overview of the advantages of using zebrafish as a vertebrate model for cilia research. We will specifically focus on the roles of cilia during zebrafish organogenesis based on recent studies. Additionally, we will highlight future prospects for ciliary research in zebrafish.

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来源期刊
Open Biology
Open Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.00
自引率
1.70%
发文量
136
审稿时长
6-12 weeks
期刊介绍: Open Biology is an online journal that welcomes original, high impact research in cell and developmental biology, molecular and structural biology, biochemistry, neuroscience, immunology, microbiology and genetics.
期刊最新文献
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