BMP 和激活素受体膜结合抑制剂:BAMBI 在基因表达和疾病中发挥多重作用(综述)。

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental and therapeutic medicine Pub Date : 2023-11-22 DOI:10.3892/etm.2023.12316
Xiaochang Chen, Jue Li, Aoqi Xiang, Hua Guan, Peihong Su, Lusha Zhang, Dian Zhang, Qi Yu
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引用次数: 0

摘要

BMP 和活化素膜结合抑制剂(BAMBI)是一种跨膜糖蛋白,被称为 TGFβ 的伪受体,因为它的胞外结构域与 I 型 TGFβ 受体相似,但胞内结构较短,缺乏丝氨酸/苏氨酸磷酸激酶信号转导基团。BAMBI 可调节多种生物现象,包括葡萄糖和脂质代谢、炎症反应以及细胞增殖和分化。此外,BAMBI 在 mRNA 和蛋白质水平的异常表达也是导致肥胖和癌症等多种人类病症的原因之一。本综述简要介绍了 BAMBI 的结构,并描述了其相关的信号通路和生理功能。了解 BAMBI 的结构和功能有助于了解肥胖和糖尿病等疾病的发生。本综述为将 BAMBI 开发为潜在的生物标志物或治疗靶点提供了理论基础。
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BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review).
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein, known as a pseudo-receptor for TGFβ, as, while its extracellular domain is similar to that of type I TGFβ receptors, its intracellular structure is shorter and lacks a serine/threonine phosphokinase signaling motif. BAMBI can regulate numerous biological phenomena, including glucose and lipid metabolism, inflammatory responses, and cell proliferation and differentiation. Furthermore, abnormal expression of BAMBI at the mRNA and protein levels contributes to various human pathologies, including obesity and cancer. In the present review, the structure of BAMBI is briefly introduced and its associated signaling pathways and physiological functions are described. Understanding of BAMBI structure and function may contribute to knowledge regarding the occurrence of diseases, including obesity and diabetes, among others. The present review provides a theoretical foundation for the development of BAMBI as a potential biomarker or therapeutic target.
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来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
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