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引用次数: 0
摘要
中肠神经内分泌肿瘤(NENs)是 NENs 中最常见的亚型之一,其发病率在全球呈上升趋势。尽管中肠神经内分泌瘤是最常见的小肠恶性肿瘤,但人们对其潜在的分子生物学却知之甚少。与其他实体瘤相比,它们的突变负荷异常低,多灶性肿瘤的发生原因不明,这使得中肠 NEN 的分子生物学成为一个特别引人入胜的研究领域。本综述概述了在了解中肠 NENs 发病过程中遗传、表观遗传和转录组的相互作用方面取得的最新进展;这一主题对于了解其生物学特性以及改善患者的治疗方案和疗效至关重要。
The Molecular Biology of Midgut Neuroendocrine Neoplasms.
Midgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumors and the unexplained occurrence of multifocal tumors makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the understanding of the interplay of the genetic, epigenetic, and transcriptomic landscape in the development of midgut NENs, a topic that is critical to understanding their biology and improving treatment options and outcomes for patients.
期刊介绍:
Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.