DNA 甲基化是女性生殖衰老的窗口。

IF 3 4区 医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2024-02-01 Epub Date: 2023-12-22 DOI:10.2217/epi-2023-0298
Anna K Knight, Jessica B Spencer, Alicia K Smith
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引用次数: 0

摘要

有卵巢的人随着生殖功能和生殖系统的衰退,会经历生殖衰老。这对生育和长期健康都有重大影响,绝经后患心脏代谢疾病的风险会增加。生殖衰老可通过卵巢储备标志物、对生育治疗的反应或分子生物标志物(包括 DNA 甲基化)进行评估。随着年龄的增长,DNA甲基化的变化与较差的生殖结果有关,而全表观基因组研究可以深入了解相关基因和途径。基于 DNA 甲基化的表观遗传时钟可以量化生殖组织和全身的生物年龄。本综述概述了生殖系统衰老的标志和理论,然后重点介绍了生殖组织中的 DNA 甲基化研究。
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DNA methylation as a window into female reproductive aging.

People with ovaries experience reproductive aging as their reproductive function and system declines. This has significant implications for both fertility and long-term health, with people experiencing an increased risk of cardiometabolic disorders after menopause. Reproductive aging can be assessed through markers of ovarian reserve, response to fertility treatment or molecular biomarkers, including DNA methylation. Changes in DNA methylation with age associate with poorer reproductive outcomes, and epigenome-wide studies can provide insight into genes and pathways involved. DNA methylation-based epigenetic clocks can quantify biological age in reproductive tissues and systemically. This review provides an overview of hallmarks and theories of aging in the context of the reproductive system, and then focuses on studies of DNA methylation in reproductive tissues.

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来源期刊
Epigenomics
Epigenomics GENETICS & HEREDITY-
CiteScore
5.80
自引率
2.60%
发文量
95
审稿时长
>12 weeks
期刊介绍: Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
期刊最新文献
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