一氧化氮介导的人体骨骼血管扩张。

IF 1.9 4区 医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2023-12-22 DOI:10.1111/micc.12842
Adina E. Draghici, Matthew R. Ely, Jason W. Hamner, J. Andrew Taylor
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引用次数: 0

摘要

目的:骨血流的调节至关重要,但人们对其了解甚少,尤其是对人类而言。本研究旨在确定一氧化氮(NO)作为其他组织血管张力的主要调节剂,是否也有助于调节骨骼的血流量:在年轻健康成人(n = 16,8F,8M)中,我们描述了一氧化氮介导的胫骨血管扩张对舌下含服硝酸甘油的反应,并将其与小腿进行对比。通过近红外光谱连续测量胫骨总血红蛋白(tHb)和小腿血流(LBF)(即同一腿部的腘绳肌血流速度),对仰卧者的血流反应进行了评估:施用 NO 后 4.4 分钟,小腿血流速度增加了 Δ9.73 ± 0.66 厘米/秒,达到峰值,随后缓慢下降,但在 10 分钟后仍保持升高(Δ3.63 ± 0.60 厘米/秒)。相比之下,胫骨的峰值反应时间更长,幅度更小,因为 tHb 增加了 Δ2.08 ± 0.22 μM,在施用 NO 后 5.3 分钟达到峰值,并迅速下降,但在 10 分钟时仍保持升高(Δ0.87±0.22 μM)(p = .01):结论:在青壮年中,胫骨血管表现出强有力的 NO 介导的血管舒张,但与 LBF 相比,tHb 的延迟和减少速度更快,这主要反映了骨骼肌的反应。因此,NO介导的骨骼血管舒张可能与其他血管床有本质区别。
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Nitric oxide-mediated vasodilation in human bone

Objective

Regulation of blood flow to bone is critical but poorly understood, particularly in humans. This study aims to determine whether nitric oxide (NO), a major regulator of vascular tone to other tissues, contributes also to the regulation of blood flow to bone.

Methods

In young healthy adults (n = 16, 8F, 8M), we characterized NO-mediated vasodilation in the tibia in response to sublingual nitroglycerin and contrasted it to lower leg. Blood flow responses were assessed in supine individuals by continuously measuring tibial total hemoglobin (tHb) via near-infrared spectroscopy and lower leg blood flow (LBF) as popliteal flow velocity via Doppler ultrasound in the same leg.

Results

LBF increased by Δ9.73 ± 0.66 cm/s and peaked 4.4 min after NO administration and declined slowly but remained elevated (Δ3.63 ± 0.60 cm/s) at 10 min. In contrast, time to peak response was longer and smaller in magnitude in the tibia as tHb increased Δ2.08 ± 0.22 μM and peaked 5.3 min after NO administration and declined quickly but remained elevated (Δ0.87±0.22 μM) at 10 min (p = .01).

Conclusions

In young adults, the tibial vasculature demonstrates robust NO-mediated vasodilation, but tHb is delayed and diminishes faster compared to LBF, predominately reflective of skeletal muscle responses. Thus, NO-mediated vasodilation in bone may be characteristically different from other vascular beds.

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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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