{"title":"糙皮病4 个 D 和 8 个点","authors":"Adrian Williams","doi":"10.47795/FBFD9966","DOIUrl":null,"url":null,"abstract":"<p><p>Pellagra has largely been forgotten. This is unfortunate as important lessons are to be learnt for the diseases and social consequences of poverty (and of affluence) that often involve dietary nicotinamide and nicotinamide adenine dinucleotide (NAD) homeostasis. NAD disruption can occur not only from poor diet but from increased consumption of NAD from genotoxic and other stresses. High doses of nicotinamide lead to inhibition of NAD-consuming enzymes and excessive induction of nicotinamide-n-methyl transferase (NNMT) with consequent effects on the methylome giving a mechanism for a new hypervitaminosis-B3.</p>","PeriodicalId":34274,"journal":{"name":"Advances in Clinical Neuroscience Rehabilitation","volume":"20 1","pages":"fbfd9966"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615395/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pellagra: 4 D's and 8 Points.\",\"authors\":\"Adrian Williams\",\"doi\":\"10.47795/FBFD9966\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pellagra has largely been forgotten. This is unfortunate as important lessons are to be learnt for the diseases and social consequences of poverty (and of affluence) that often involve dietary nicotinamide and nicotinamide adenine dinucleotide (NAD) homeostasis. NAD disruption can occur not only from poor diet but from increased consumption of NAD from genotoxic and other stresses. High doses of nicotinamide lead to inhibition of NAD-consuming enzymes and excessive induction of nicotinamide-n-methyl transferase (NNMT) with consequent effects on the methylome giving a mechanism for a new hypervitaminosis-B3.</p>\",\"PeriodicalId\":34274,\"journal\":{\"name\":\"Advances in Clinical Neuroscience Rehabilitation\",\"volume\":\"20 1\",\"pages\":\"fbfd9966\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615395/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Clinical Neuroscience Rehabilitation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47795/FBFD9966\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Clinical Neuroscience Rehabilitation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47795/FBFD9966","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
糙皮病在很大程度上已被人们遗忘。这是令人遗憾的，因为我们可以从贫困（和富裕）带来的疾病和社会后果中汲取重要的经验教训，这些疾病和社会后果往往涉及膳食中的烟酰胺和烟酰胺腺嘌呤二核苷酸（NAD）平衡。NAD 失调不仅可能是饮食不当造成的，也可能是基因毒性和其他压力导致 NAD 消耗量增加造成的。高剂量的烟酰胺会导致抑制消耗 NAD 的酶和过度诱导烟酰胺-甲基转移酶（NNMT），从而对甲基组产生影响，这就是新的维生素 B3 过多症的机制。
Pellagra has largely been forgotten. This is unfortunate as important lessons are to be learnt for the diseases and social consequences of poverty (and of affluence) that often involve dietary nicotinamide and nicotinamide adenine dinucleotide (NAD) homeostasis. NAD disruption can occur not only from poor diet but from increased consumption of NAD from genotoxic and other stresses. High doses of nicotinamide lead to inhibition of NAD-consuming enzymes and excessive induction of nicotinamide-n-methyl transferase (NNMT) with consequent effects on the methylome giving a mechanism for a new hypervitaminosis-B3.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
