杏仁核-感觉运动连通性的降低介导了产前压力与青少年广泛自闭症表型之间的关联:冰风暴项目

IF 2.6 4区 心理学 Q2 BEHAVIORAL SCIENCES Stress-The International Journal on the Biology of Stress Pub Date : 2024-01-01 Epub Date: 2023-12-22 DOI:10.1080/10253890.2023.2293698
Xinyuan Li, Muhammad Naveed Iqbal Qureshi, David P Laplante, Guillaume Elgbeili, Vincent Paquin, Sherri Lee Jones, Suzanne King, Pedro Rosa-Neto
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引用次数: 0

摘要

研究表明,产前母亲压力(PNMS)与儿童自闭症的风险以及自闭症儿童的非典型杏仁核功能连接有关。然而,杏仁核功能连接是否会介导产前母体压力与自闭症特征之间的关联,尤其是在年轻的成年后代中,目前仍不清楚。我们招募了在1998年魁北克冰风暴危机期间或危机后3个月内怀孕的妇女,并对PNMS的三个方面进行了评估:客观困难(冰风暴期间经历的事件)、主观痛苦(冰风暴导致的创伤后应激症状)和认知评估。32 名 19 岁的年轻人(21 名女性)自我报告了他们的自闭症样特征(即冷漠性格、实用性语言障碍和刻板性格),并接受了结构性核磁共振成像和静息状态功能性核磁共振成像扫描。研究人员进行了种子到象素分析,以绘制杏仁核功能连接网络图。通过对 20,000 个重置点进行引导,进行了中介分析。我们发现,产妇的客观困难越大,左侧杏仁核和右侧中央后回之间的功能连接就越弱,而这又与更多的实用性语言障碍有关。产妇的主观痛苦越大,右侧杏仁核和左侧中央前回之间的功能连接性就越弱,而这又与更冷漠的性格有关。我们的研究结果表明,PNMS 对后代自闭症样特征的长期影响可能是由杏仁核-感觉运动回路的减少介导的。杏仁核-感觉和杏仁核-运动通路在介导PNMS对不同自闭症表型的不同影响方面的差异还需要进一步研究。
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Decreased amygdala-sensorimotor connectivity mediates the association between prenatal stress and broad autism phenotype in young adults: Project Ice Storm.

Studies show that prenatal maternal stress (PNMS) is related to risk for child autism, and to atypical amygdala functional connectivity in the autistic child. Yet, it remains unclear whether amygdala functional connectivity mediates the association between PNMS and autistic traits, particularly in young adult offspring. We recruited women who were pregnant during, or within 3 months of, the 1998 Quebec ice storm crisis, and assessed three aspects of PNMS: objective hardship (events experienced during the ice storm), subjective distress (post-traumatic stress symptoms experienced as a result of the ice storm) and cognitive appraisal. At age 19, 32 young adults (21 females) self-reported their autistic-like traits (i.e., aloof personality, pragmatic language impairment and rigid personality), and underwent structural MRI and resting-state functional MRI scans. Seed-to-voxel analyses were conducted to map the amygdala functional connectivity network. Mediation analyses were implemented with bootstrapping of 20,000 resamplings. We found that greater maternal objective hardship was associated with weaker functional connectivity between the left amygdala and the right postcentral gyrus, which was then associated with more pragmatic language impairment. Greater maternal subjective distress was associated with weaker functional connectivity between the right amygdala and the left precentral gyrus, which was then associated with more aloof personality. Our results demonstrate that the long-lasting effect of PNMS on offspring autistic-like traits may be mediated by decreased amygdala-sensorimotor circuits. The differences between amygdala-sensory and amygdala-motor pathways mediating different aspects of PNMS on different autism phenotypes need to be studied further.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
25
审稿时长
6-12 weeks
期刊介绍: The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
期刊最新文献
Inhibition of prefrontal cortex parvalbumin interneurons mitigates behavioral and physiological sequelae of chronic stress in male mice. Maternal prenatal distress exposure negatively associates with the stability of neonatal frontoparietal network. Decreased amygdala-sensorimotor connectivity mediates the association between prenatal stress and broad autism phenotype in young adults: Project Ice Storm. Accumbal μ-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics. Behavior, synaptic mitochondria, and microglia are differentially impacted by chronic adolescent stress and repeated endotoxin exposure in male and female rats.
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