Matheus Costa, Igor Jorge, Patricia Martin, Renato Nisihara, Thelma Skare
{"title":"男性和女性硬皮病患者：巴西样本比较研究。","authors":"Matheus Costa, Igor Jorge, Patricia Martin, Renato Nisihara, Thelma Skare","doi":"10.46497/ArchRheumatol.2023.10011","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females and males.</p><p><strong>Patients and methods: </strong>This retrospective study was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.5 years; range, 16 to 88 years) between September 2005 and September 2020. Disease severity was calculated by the Medsger severity score. Males and females were compared for clinical and serological markers.</p><p><strong>Results: </strong>Females more frequently had esophageal involvement (p=0.003), telangiectasias (p=0.03), and antinuclear antibodies (p=0.04). Males more frequently had fingertip scars (p=0.03), digital ulcers (p=0.006), and a worse median Medsger severity score (6 in males <i>vs.</i> 4 in females, p=0.05).</p><p><strong>Conclusion: </strong>In the studied sample, males had more severe disease than females with greater repercussions in periferic circulatory system.</p>","PeriodicalId":93884,"journal":{"name":"Archives of rheumatology","volume":"38 4","pages":"542-548"},"PeriodicalIF":1.1000,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728735/pdf/","citationCount":"0","resultStr":"{\"title\":\"Males and females with scleroderma: A comparative study in a Brazilian sample.\",\"authors\":\"Matheus Costa, Igor Jorge, Patricia Martin, Renato Nisihara, Thelma Skare\",\"doi\":\"10.46497/ArchRheumatol.2023.10011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females and males.</p><p><strong>Patients and methods: </strong>This retrospective study was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.5 years; range, 16 to 88 years) between September 2005 and September 2020. Disease severity was calculated by the Medsger severity score. Males and females were compared for clinical and serological markers.</p><p><strong>Results: </strong>Females more frequently had esophageal involvement (p=0.003), telangiectasias (p=0.03), and antinuclear antibodies (p=0.04). Males more frequently had fingertip scars (p=0.03), digital ulcers (p=0.006), and a worse median Medsger severity score (6 in males <i>vs.</i> 4 in females, p=0.05).</p><p><strong>Conclusion: </strong>In the studied sample, males had more severe disease than females with greater repercussions in periferic circulatory system.</p>\",\"PeriodicalId\":93884,\"journal\":{\"name\":\"Archives of rheumatology\",\"volume\":\"38 4\",\"pages\":\"542-548\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728735/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of rheumatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46497/ArchRheumatol.2023.10011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46497/ArchRheumatol.2023.10011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Males and females with scleroderma: A comparative study in a Brazilian sample.
Objectives: This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females and males.
Patients and methods: This retrospective study was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.5 years; range, 16 to 88 years) between September 2005 and September 2020. Disease severity was calculated by the Medsger severity score. Males and females were compared for clinical and serological markers.
Results: Females more frequently had esophageal involvement (p=0.003), telangiectasias (p=0.03), and antinuclear antibodies (p=0.04). Males more frequently had fingertip scars (p=0.03), digital ulcers (p=0.006), and a worse median Medsger severity score (6 in males vs. 4 in females, p=0.05).
Conclusion: In the studied sample, males had more severe disease than females with greater repercussions in periferic circulatory system.
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