{"title":"利用 MMP-7 水平和胆汁酸的综合模型准确预测胆道闭锁。","authors":"Yi-Jiang Han, Shu-Qi Hu, Jin-Hang Zhu, Xiao Cai, Deng-Ming Lai, Bao-Hai Chen, Kun Zhu, Qiao Tong, Xin-Rui Zhou, Jia-Le Deng, Jin-Fa Tou, Zhuo Fang, Li-Zhong Du","doi":"10.1007/s12519-023-00779-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Biliary atresia (BA) is a rare fatal liver disease in children, and the aim of this study was to develop a method to diagnose BA early.</p><p><strong>Methods: </strong>We determined serum levels of matrix metalloproteinase-7 (MMP-7), the results of 13 liver tests, and the levels of 20 bile acids, and integrated computational models were constructed to diagnose BA.</p><p><strong>Results: </strong>Our findings demonstrated that MMP-7 expression levels, as well as the results of four liver tests and levels of ten bile acids, were significantly different between 86 BA and 59 non-BA patients (P < 0.05). The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy [area under the receiver operating characteristic curve (AUC) = 0.966, 95% confidence interval (CI): 0.942, 0.989] than liver test results and bile acid levels. The AUC was 0.890 (95% CI 0.837, 0.943) for liver test results and 0.825 (95% CI 0.758, 0.892) for bile acid levels. Furthermore, bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels (AUC = 0.976, 95% CI 0.953, 1.000) than liver test results. The AUC was 0.983 (95% CI 0.962, 1.000) for MMP-7 levels combined with liver test results and bile acid levels. In addition, we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis score.</p><p><strong>Conclusion: </strong>The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children. Video Abstract (MP4 142103 KB).</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402860/pdf/","citationCount":"0","resultStr":"{\"title\":\"Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids.\",\"authors\":\"Yi-Jiang Han, Shu-Qi Hu, Jin-Hang Zhu, Xiao Cai, Deng-Ming Lai, Bao-Hai Chen, Kun Zhu, Qiao Tong, Xin-Rui Zhou, Jia-Le Deng, Jin-Fa Tou, Zhuo Fang, Li-Zhong Du\",\"doi\":\"10.1007/s12519-023-00779-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Biliary atresia (BA) is a rare fatal liver disease in children, and the aim of this study was to develop a method to diagnose BA early.</p><p><strong>Methods: </strong>We determined serum levels of matrix metalloproteinase-7 (MMP-7), the results of 13 liver tests, and the levels of 20 bile acids, and integrated computational models were constructed to diagnose BA.</p><p><strong>Results: </strong>Our findings demonstrated that MMP-7 expression levels, as well as the results of four liver tests and levels of ten bile acids, were significantly different between 86 BA and 59 non-BA patients (P < 0.05). The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy [area under the receiver operating characteristic curve (AUC) = 0.966, 95% confidence interval (CI): 0.942, 0.989] than liver test results and bile acid levels. The AUC was 0.890 (95% CI 0.837, 0.943) for liver test results and 0.825 (95% CI 0.758, 0.892) for bile acid levels. Furthermore, bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels (AUC = 0.976, 95% CI 0.953, 1.000) than liver test results. The AUC was 0.983 (95% CI 0.962, 1.000) for MMP-7 levels combined with liver test results and bile acid levels. In addition, we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis score.</p><p><strong>Conclusion: </strong>The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children. 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引用次数: 0
摘要
背景:胆道闭锁(BA)是一种罕见的儿童致命性肝病:胆道闭锁(BA)是一种罕见的儿童致命性肝病,本研究旨在开发一种早期诊断BA的方法:方法:我们测定了血清基质金属蛋白酶-7(MMP-7)的水平、13项肝脏检查结果和20种胆汁酸的水平,并构建了诊断胆道闭锁的综合计算模型:结果:我们的研究结果表明,86 例 BA 患者和 59 例非 BA 患者的基质金属蛋白酶-7 表达水平、4 项肝脏检查结果和 10 种胆汁酸的水平均有显著差异(P 结论:基质金属蛋白酶-7 表达水平、4 项肝脏检查结果和 10 种胆汁酸的水平均有显著差异(P):基于大量指标的创新综合模型为准确诊断儿童 BA 提供了一种无创、经济有效的方法。视频摘要(MP4 142103 KB)。
Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids.
Background: Biliary atresia (BA) is a rare fatal liver disease in children, and the aim of this study was to develop a method to diagnose BA early.
Methods: We determined serum levels of matrix metalloproteinase-7 (MMP-7), the results of 13 liver tests, and the levels of 20 bile acids, and integrated computational models were constructed to diagnose BA.
Results: Our findings demonstrated that MMP-7 expression levels, as well as the results of four liver tests and levels of ten bile acids, were significantly different between 86 BA and 59 non-BA patients (P < 0.05). The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy [area under the receiver operating characteristic curve (AUC) = 0.966, 95% confidence interval (CI): 0.942, 0.989] than liver test results and bile acid levels. The AUC was 0.890 (95% CI 0.837, 0.943) for liver test results and 0.825 (95% CI 0.758, 0.892) for bile acid levels. Furthermore, bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels (AUC = 0.976, 95% CI 0.953, 1.000) than liver test results. The AUC was 0.983 (95% CI 0.962, 1.000) for MMP-7 levels combined with liver test results and bile acid levels. In addition, we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis score.
Conclusion: The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children. Video Abstract (MP4 142103 KB).
期刊介绍:
The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics.
We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.