使用哌醋甲酯时出现意外子宫失血

I. Gybels, F.-L. De Winter, Y. Meuffels
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摘要

哌醋甲酯诱发的意外子宫出血 在大多数国家,哌醋甲酯似乎是治疗注意力缺陷多动障碍(ADHD)的主要药物。据估计,多动症的全球发病率在成人中约为 2.5%,在儿童中约为 5-7%。本病例报告探讨了一名患者开始服用缓释哌醋甲酯与意外子宫出血之间的联系,旨在确定将这一症状视为哌醋甲酯副作用是否有科学依据。尽管文献中存在一些疑点,但要解释哌醋甲酯与意外子宫出血之间的因果关系,证据仍然过于有限。近年来,科学研究表明,女性人群对多动症的认识在不断提高,而以前女性和女孩被诊断为多动症的频率要低得多,时间也要晚得多。然而,在现有的科学文献中,尤其是在一些较早的研究中,仍然存在女性比例偏低的现象。在未来的研究中,一个重要的挑战在于进一步监测哌醋甲酯对女性生殖系统的任何潜在影响,充分报告研究人群中避孕药具的使用情况,以及详细说明所有不良事件和研究退出的原因。
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Onverwacht uterien bloedverlies bij methylfenidaat
Unexpected methylphenidate-induced uterine bleeding In most countries, methylphenidate appears to be the main pharmacological treatment for attention deficit hyperactivity disorder (ADHD). The global prevalence of ADHD is estimated to be approximately 2.5% in adults and 5-7% in children. This case report examines the link between the initiation of extended-release methylphenidate and the occurrence of unexpected uterine bleeding in a patient, aiming to determine if there is any scientific basis for considering this symptom as a side effect of methylphenidate. Although there are some suspicions in the literature, the evidence is still too limited to explain a causal relationship between methylphenidate and unexpected uterine bleeding. In recent years, scientific studies have shown a growing awareness of ADHD in the female population, while women and girls were previously diagnosed with ADHD much less frequently and much later. However, this phenomenon of underrepresentation of women still occurs in the available scientific literature, especially in somewhat older studies. In future research, an important challenge lies in further monitoring any potential effects of methylphenidate on the female reproductive system, adequately reporting contraceptive use in study populations, as well as detailing all adverse events and reasons for study dropouts.
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Begint het huisartsentekort bij de opleiding? Begint het huisartsentekort bij de opleiding? Een onderzoek naar het gebruik van de Pediatric Sleep Questionnaire als screeningstool voor obstructief slaapapneusyndroom bij kinderen met ADHD Een onderzoek naar het gebruik van de Pediatric Sleep Questionnaire als screeningstool voor obstructief slaapapneusyndroom bij kinderen met ADHD Methylfenidaat als behandeling voor hypersomnolentie als gevolg van een thalamusinfarct
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