伴有包涵体疾病的红尾蟒同时患有弥漫性 B 细胞淋巴瘤和副神经节瘤

Megan Coyne, J. Struthers, Matti Kiupel
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摘要

摘要 一条 15 岁的雄性圈养红尾蟒蛇(Boa constrictor constrictor)因反应迟钝和侧卧而被安乐术后送检。该蛇有呼吸道疾病史、腹腔肿胀、白细胞胞浆内包涵体,死前 Reptarenavirus PCR 呈阴性。尸体解剖时,发现肺部和整个消化道内有白色实性肿块,心包和心底血管前壁有坚实光滑的黄色肿块。组织病理学检查发现,无弹性大细胞淋巴瘤浸润了多种组织类型,其中肺部和食道最为严重。肿瘤淋巴细胞 CD3 阴性,Pax5 阳性,与 B 细胞淋巴瘤一致。黄色的心包肿块由肿瘤性神经内分泌细胞组成,这些细胞具有中等数量的空泡化胞质和卵圆形小核,核内染色质呈细条纹状排列,被细小的纤维血管基质隔开。肿瘤细胞的β-内啡肽呈阳性,与副神经节瘤的诊断一致。此外,包括肿瘤性淋巴细胞和神经内分泌细胞在内的许多细胞类型都含有细胞质病毒性嗜酸性包涵体,脾脏上的 Reptarenavirus PCR 检测到一种 Reptarenavirus giessenae 病毒。这条蛇被诊断为并发副神经节瘤、包涵体病和无弹性淋巴瘤,形态上表现为B细胞表型的弥漫性淋巴瘤。Reptarenavirus 是否会导致蛇类肿瘤尚存在争议。本病例描述了一条同时感染了 Reptarenavirus 病毒的蛇的多种肿瘤。
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Concurrent Diffuse B-cell Lymphoma and Paraganglioma in a Red-tailed Boa (Boa constrictor constrictor) with Inclusion Body Disease
Abstract A 15-yr-old, male, captive red-tailed boa (Boa constrictor constrictor) was submitted for postmortem examination after it was euthanized after becoming nonresponsive and laterally recumbent. The snake had a history of respiratory disease, coelomic swelling, leukocyte intracytoplasmic inclusion bodies, and an antemortem negative Reptarenavirus PCR. At necropsy, there were solid white masses in the lungs and throughout the alimentary tract, and firm, smooth yellow masses in the pericardium and adventitia of heart base vessels. Histopathology revealed an anaplastic large-cell lymphoma that infiltrated multiple tissue types, most severely the lungs and esophagus. Neoplastic lymphocytes were negative for CD3 and positive for Pax5, consistent with a B-cell lymphoma. The yellow pericardial masses were composed of neoplastic neuroendocrine cells with moderate amounts of vacuolated cytoplasm and small, ovoid nuclei with finely stippled chromatin arranged in packets separated by fine fibrovascular stroma. Neoplastic cells were positive for β-endorphin consistent with a diagnosis of paraganglioma. Additionally, many cell types, including neoplastic lymphocytes and neuroendocrine cells, contained cytoplasmic viral eosinophilic inclusions, and Reptarenavirus PCR on spleen detected a virus in the species Reptarenavirus giessenae. This snake was diagnosed with concurrent paraganglioma, inclusion body disease, and anaplastic lymphoma, morphologically represented as a diffuse lymphoma of B-cell phenotype. Whether Reptarenavirus predisposes to neoplasia in snakes is debated. This case describes multiple neoplasms in a snake with a concurrent Reptarenavirus infection.
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