基于脂质和聚合物的纳米植物疗法

IF 3.3 Q3 NANOSCIENCE & NANOTECHNOLOGY Nanofabrication Pub Date : 2023-12-20 DOI:10.37819/nanofab.8.1773
O. Bagade, Priyanka E. Doke-Bagade, Siddhesh E. Doke, Krushna S. Wankhade
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引用次数: 0

摘要

高效给药系统的开发在现代药物疗法中至关重要,其目的是提高生物药效,同时最大限度地减少药物的不良反应。近期的重点已转向含脂质和聚合物的纳米植物疗法,将天然材料和合成材料的优势结合在一起。脂质体和脂质纳米颗粒等含脂纳米载体特别适合封装疏水性植物化学物质,从而提高其生物利用度和稳定性。加入壳聚糖和聚乙二醇等生物可降解聚合物有助于控制释放和靶向给药。此外,与合成药物相比,利用植物提取的植物化学物质可降低毒性。本章概述了这一领域的研究现状,强调了脂基纳米载体和生物相容性聚合物在植物化学物质递送方面的协同潜力。研究策略包括配方技术、表面修饰和靶向药物释放机制。此外,还讨论了这些系统在治疗各种疾病(包括癌症、心血管疾病和传染病)方面的潜在应用。总之,基于脂质和聚合物的纳米植物疗法有望成为适应性强、生物相容性好的给药平台,预示着高效和靶向植物化学物质给药的好处,有可能给现代医学带来革命性的变化。预计这一领域的进一步发展将产生新的治疗方案,提高临床疗效,减少副作用。
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Lipid And Polymer Based Nano-Phytotherapeutics
The development of efficient drug delivery systems is pivotal in modern pharmacotherapy, aiming to enhance biological efficacy while minimizing the adverse effects of pharmaceutical agents. Recent focus has shifted towards lipid as well as polymer-containing nano-phytotherapeutics, amalgamating the benefits of natural and synthetic materials. Lipid-containing nanocarriers, like liposomes and lipid nanoparticles, are particularly suited for encapsulating hydrophobic phytochemicals, thereby augmenting their bioavailability and stability. Incorporating biodegradable polymers like chitosan and polyethylene glycol facilitates controlled release and target-specific delivery. Furthermore, the utilization of plant-derived phytochemicals offers reduced toxicity compared to synthetic drugs. This chapter outlines current research in this domain, emphasizing the synergistic potential of lipid-based nanocarriers and biocompatible polymers for phytochemical delivery. Strategies encompass formulation techniques, surface modifications, and targeted drug release mechanisms. The potential applications of these systems in treating diverse diseases, including cancer, cardiovascular disorders, and infectious diseases, are also discussed. Overall, lipid and polymer-based Nano-phytotherapeutics exhibit promise as adaptable and biocompatible drug delivery platforms, heralding benefits for efficient and targeted phytochemical delivery, potentially revolutionizing modern medicine. Further advancement in this field is anticipated to yield novel therapeutic solutions with enhanced clinical outcomes and reduced side effects.
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来源期刊
Nanofabrication
Nanofabrication NANOSCIENCE & NANOTECHNOLOGY-
自引率
10.30%
发文量
13
审稿时长
16 weeks
期刊最新文献
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