研究 COVID-19 患者的代谢组特征

Y. V. Russkikh, N. Sushentseva, O. Popov, S. Apalko, A. Anisenkova, S. V. Mosenko, A. Sarana, S. G. Shcherbak
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引用次数: 0

摘要

目的利用质谱方法,结合临床和实验室病史,分析冠状病毒病 2019(COVID-19)患者的代谢组谱。研究 COVID-19 症状严重程度与主要代谢物(主要是氨基酸)浓度之间的关系。这项回顾性研究包括市立医院№40生物库收集的935名COVID-19患者(男性445人,女性490人)的血清样本。使用色谱-质谱法对所有样本进行了代谢组学分析。使用 R 语言进行数据统计处理。根据分析结果,COVID-19 患者的代谢概况因疾病严重程度不同而存在差异--在检测到的 84 种化合物中,52 种存在差异,差异显著性为 p<0.01。有机酸、氨基酸及其衍生物的浓度存在显著差异。利用生物库收集的样本,对确诊为 COVID-19 的住院患者的生物材料进行了代谢组学研究。研究结果表明,犬尿氨酸、苯丙氨酸和乙酰肉碱与 COVID-19 的严重程度有关。在采集血液时发现细胞因子风暴患者的代谢组学特征存在差异。确定了细胞因子风暴的潜在生物标志物。
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Study of the metabolome features of patients with COVID-19
Aim. To analyze the metabolomic profile of patients with coronavirus disease 2019 (COVID-19) using mass spectrometry methods and taking into account clinical and laboratory history. Studying the relationship between the severity of COVID-19 symptoms and the concentration of primary metabolites, primarily amino acids.Material and methods. The retrospective study included serum samples from a total of 935 people (445 men and 490 women) with COVID-19 from the collection of the biobank of the City Hospital № 40. A metabolomic profile was studied in all samples using chromatography-mass spectrometry. The R language was used for statistical data processing.Results. Based on the analysis, a difference in the metabolic profile of patients with COVID-19 was identified depending on the disease severity — for 52 of the 84 detected compounds, differences were observed with a significance of p<0,01. Significant differences in concentration were recorded for organic acids, amino acids and their derivatives.Conclusion. Using samples from the biobank collection, a metabolomic study of the biomaterial of patients hospitalized with a diagnosis of COVID-19 was carried out. According to the results obtained, kynurenine, phenylalanine and acetylcarnitine are associated with COVID-19 severity. Differences in the metabolomic profile were identified in patients with cytokine storm at the time of blood collection. Potential biomarkers for cytokine storm were identified.
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来源期刊
Cardiovascular Therapy and Prevention
Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.70
自引率
0.00%
发文量
155
审稿时长
6-12 weeks
期刊介绍: The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.
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