基于磁性纳米粒子和金属有机框架的纳米复合材料在治疗、诊断和热诊断中的应用

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY ACS Nanoscience Au Pub Date : 2023-12-23 DOI:10.1021/acsnanoscienceau.3c00041
Darina Francesca Picchi, Catalina Biglione and Patricia Horcajada*, 
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摘要

在过去的二十年里,具有高度可调结构和孔隙率的金属有机框架(MOFs)已成为生物医学领域的药物纳米载体。特别是纳米级 MOFs(nanoMOFs),由于其潜在的生物相容性、高载药量和渐进释放特性,已被广泛研究。为了增强其特性,人们将 MOFs 与磁性纳米粒子(MNPs)结合,形成具有附加功能的磁性纳米复合材料(MNP@MOF)。由于 MNPs 的磁性,它们在纳米系统中的存在使潜在的组合磁性靶向治疗和诊断成为可能。在本综述中,我们分析了目前用于制造 MNP@MOF 纳米复合材料的四种主要合成策略,即混合法、在预合成的 MOF 中原位形成 MNPs 法、在 MNPs 存在的情况下原位形成 MOFs 法以及逐层法。此外,我们还讨论了生物应用方面的最新进展,重点是药物输送系统 (DDS)、磁共振成像 (MRI)、磁热疗法 (MHT) 和恒温系统。总之,我们全面概述了 MNP@MOF 纳米复合材料在开发和生物应用方面的最新进展,强调了它们在未来生物医学应用中的潜力,并对这些纳米复合材料在合成、表征、生物相容性和应用性方面面临的挑战和局限性进行了深入分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nanocomposites Based on Magnetic Nanoparticles and Metal–Organic Frameworks for Therapy, Diagnosis, and Theragnostics

In the last two decades, metal–organic frameworks (MOFs) with highly tunable structure and porosity, have emerged as drug nanocarriers in the biomedical field. In particular, nanoscaled MOFs (nanoMOFs) have been widely investigated because of their potential biocompatibility, high drug loadings, and progressive release. To enhance their properties, MOFs have been combined with magnetic nanoparticles (MNPs) to form magnetic nanocomposites (MNP@MOF) with additional functionalities. Due to the magnetic properties of the MNPs, their presence in the nanosystems enables potential combinatorial magnetic targeted therapy and diagnosis. In this Review, we analyze the four main synthetic strategies currently employed for the fabrication of MNP@MOF nanocomposites, namely, mixing, in situ formation of MNPs in presynthesized MOF, in situ formation of MOFs in the presence of MNPs, and layer-by-layer methods. Additionally, we discuss the current progress in bioapplications, focusing on drug delivery systems (DDSs), magnetic resonance imaging (MRI), magnetic hyperthermia (MHT), and theragnostic systems. Overall, we provide a comprehensive overview of the recent advances in the development and bioapplications of MNP@MOF nanocomposites, highlighting their potential for future biomedical applications with a critical analysis of the challenges and limitations of these nanocomposites in terms of their synthesis, characterization, biocompatibility, and applicability.

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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
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0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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