将神经振荡的相位作为视觉皮层基于注意力的路由参考框架

IF 6.7 2区 医学 Q1 NEUROSCIENCES Progress in Neurobiology Pub Date : 2023-12-23 DOI:10.1016/j.pneurobio.2023.102563
Ehsan Aboutorabi , Sonia Baloni Ray , Daniel Kaping , Farhad Shahbazi , Stefan Treue , Moein Esghaei
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引用次数: 0

摘要

选择性注意使大脑能够有效地处理投射到视网膜上的图像,有选择性地将神经处理资源集中在与行为相关的视觉信息上。虽然之前的研究已经证明了单个神经元的动作电位率在传递此类信息中的关键作用,但人们对单个神经元相对于其邻近网络的活动如何有助于有效地表征注意到的刺激并将这些信息传递到下游区域却知之甚少。在这里,我们在猴子的背侧视觉通路(内侧颞上区)中发现,神经元会优先在周围局部网络正在进行的群体贝塔(~20Hz)振荡的特定阶段发射尖峰脉冲。当猴子选择性地注意神经元感受野(而不是远离感受野)时,这种偏好的尖峰相位就会向较晚的相位移动。这种锁定相位的转移与动物报告视觉变化的速度呈正相关。此外,我们的计算模型还表明,神经网络可以通过对突触后电位施加不同的突触延迟来操纵首选的耦合阶段。这种空间刺激激活的神经元锁定阶段与非空间刺激激活的神经元锁定阶段之间的区别,可能使神经系统能够区分相关与不相关的感觉输入,并通过将传递相关/不相关信息的尖峰对准与高级皮层较好/较差的感知敏感期相关联的不同阶段,从而过滤掉干扰性刺激信息。这种策略可用于保留知觉效率最高的狭窄窗口,以处理与行为最相关的信息,确保对关注的感觉事件做出高效反应。
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Phase of neural oscillations as a reference frame for attention-based routing in visual cortex

Selective attention allows the brain to efficiently process the image projected onto the retina, selectively focusing neural processing resources on behaviorally relevant visual information. While previous studies have documented the crucial role of the action potential rate of single neurons in relaying such information, little is known about how the activity of single neurons relative to their neighboring network contributes to the efficient representation of attended stimuli and transmission of this information to downstream areas. Here, we show in the dorsal visual pathway of monkeys (medial superior temporal area) that neurons fire spikes preferentially at a specific phase of the ongoing population beta (∼20 Hz) oscillations of the surrounding local network. This preferred spiking phase shifts towards a later phase when monkeys selectively attend towards (rather than away from) the receptive field of the neuron. This shift of the locking phase is positively correlated with the speed at which animals report a visual change. Furthermore, our computational modeling suggests that neural networks can manipulate the preferred phase of coupling by imposing differential synaptic delays on postsynaptic potentials. This distinction between the locking phase of neurons activated by the spatially attended stimulus vs. that of neurons activated by the unattended stimulus, may enable the neural system to discriminate relevant from irrelevant sensory inputs and consequently filter out distracting stimuli information by aligning the spikes which convey relevant/irrelevant information to distinct phases linked to periods of better/worse perceptual sensitivity for higher cortices. This strategy may be used to reserve the narrow windows of highest perceptual efficacy to the processing of the most behaviorally relevant information, ensuring highly efficient responses to attended sensory events.

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来源期刊
Progress in Neurobiology
Progress in Neurobiology 医学-神经科学
CiteScore
12.80
自引率
1.50%
发文量
107
审稿时长
33 days
期刊介绍: Progress in Neurobiology is an international journal that publishes groundbreaking original research, comprehensive review articles and opinion pieces written by leading researchers. The journal welcomes contributions from the broad field of neuroscience that apply neurophysiological, biochemical, pharmacological, molecular biological, anatomical, computational and behavioral analyses to problems of molecular, cellular, developmental, systems, and clinical neuroscience.
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