东辽黑猪出生仔猪成活和死亡数量的全基因组关联研究。

IF 1.8 3区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal genetics Pub Date : 2023-12-26 DOI:10.1111/age.13385

Hao Sun, Yu Cheng, Yu He, Chao Cheng, Hongxia Zhao, Sumei Yang, Meng Wei, Jingxiu Yang, Shuang Liang, Chunyan Bai, Boxing Sun

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引用次数: 0

摘要

产仔数（出生总头数）特性对猪肉生产的经济成就有很大影响。总出生头数包括活产仔猪头数和死产仔猪头数。为阐明窝产仔数的遗传背景，本研究开展了全基因组关联研究。研究人员采集了 723 头东辽黑母猪的 DNA 样本，并使用 Porcine 50K BeadChip 进行了基因分型。使用三种不同的模型（BLINK、FarmCPU 和 MLM），共发现了 155 个显著的 SNPs，其中 6 个 SNPs 曾在之前的猪繁殖关联研究中报道过。我们认为，位于 GLI3 基因的 rs81318434 可能是影响产仔数性状的候选基因。我们的研究结果可为揭示猪产仔数的遗传机制提供启示。

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Genome-wide association studies for the number of piglets born alive and dead in Dongliao black pigs

Litter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous pig reproduction association studies. We suggest that rs81318434, located in the GLI3 gene, might be the promising candidate affecting litter size trait. Our findings may provide insights for uncovering the genetic mechanisms for the litter size of pigs.

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来源期刊

Animal genetics 生物-奶制品与动物科学

CiteScore

4.60

自引率

4.20%

发文量

115

审稿时长

5 months

期刊介绍： Animal Genetics reports frontline research on immunogenetics, molecular genetics and functional genomics of economically important and domesticated animals. Publications include the study of variability at gene and protein levels, mapping of genes, traits and QTLs, associations between genes and traits, genetic diversity, and characterization of gene or protein expression and control related to phenotypic or genetic variation. The journal publishes full-length articles, short communications and brief notes, as well as commissioned and submitted mini-reviews on issues of interest to Animal Genetics readers.