三氧化二砷：迄今为止的应用、作用机制、毒性和救治策略。

IF 6.9 3区医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-12-26 DOI:10.1007/s12272-023-01481-y

Meng Yan, Hao Wang, Rui Wei, Wenwen Li

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引用次数: 0

摘要

砒霜在中国传统医学中的地位已有两千多年的历史。20 世纪 70 年代，三氧化二砷被发现对治疗急性早幼粒细胞白血病有很高的疗效和效力，从而促进了许多关于三氧化二砷治疗作用的研究。目前，三氧化二砷在临床上通过各种作用机制被广泛用于治疗急性早幼粒细胞白血病和各种实体瘤，但同时也伴随着一系列不良反应，尤其是心脏毒性。本综述从临床前和临床疗效、潜在作用机制、毒性以及毒性救治策略等方面对三氧化二砷进行了全面概述，以期为三氧化二砷的临床应用提供指导或帮助。

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Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date

Arsenical medicine has obtained its status in traditional Chinese medicine for more than 2,000 years. In the 1970s, arsenic trioxide was identified to have high efficacy and potency for the treatment of acute promyelocytic leukemia, which promoted many studies on the therapeutic effects of arsenic trioxide. Currently, arsenic trioxide is widely used to treat acute promyelocytic leukemia and various solid tumors through various mechanisms of action in clinical practice; however, it is accompanied by a series of adverse reactions, especially cardiac toxicity. This review presents a comprehensive overview of arsenic trioxide from preclinical and clinical efficacy, potential mechanisms of action, toxicities, and rescue strategies for toxicities to provide guidance or assistance for the clinical application of arsenic trioxide.

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.