利用无细胞 DNA 技术在一名感染性心内膜炎患者的血液中发现氢化厌氧球菌。

IF 1.7 Q3 INFECTIOUS DISEASES GERMS Pub Date : 2023-09-30 eCollection Date: 2023-09-01 DOI:10.18683/germs.2023.1396
Tulika Chatterjee, Moni Roy, Yeshaswini Panathur Sreenivasa Reddy, Sharjeel Ahmad
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引用次数: 0

摘要

导言:在发达国家,感染性心内膜炎(IE)的年发病率为每十万人中3-9例,大多数病例由葡萄球菌和链球菌引起。革兰氏阳性厌氧球菌(GPAC)引起的 IE 非常罕见:我们报告了一例 38 岁女性的病例,她患有氢化厌氧球菌菌血症和原发性二尖瓣感染性心内膜炎。患者出现发热、寒战和腹痛。腹部计算机断层扫描显示有脾脓肿。脾脓肿样本的血液培养和广谱 PCR 结果均为阴性。经胸超声心动图显示,二尖瓣前叶心房侧有一个移动的丝状结构,提示感染性心内膜炎。卡里乌斯试验(无细胞微生物 DNA 检测)显示,患者体内存在革兰氏阳性厌氧球菌氢化厌氧球菌。她成功地接受了抗生素治疗:结论:在感染 GPACs 等快速微生物的病例中,使用新一代测序技术(NGS)可以正确识别罪魁祸首病原体并简化治疗。
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Finding of Anaerococcus hydrogenalis in blood using cell-free DNA technique in a patient with infective endocarditis.

Introduction: The annual incidence of infective endocarditis (IE) is 3-9 cases per 100000 in developed countries and most cases are due to staphylococci and streptococci. IE due to Gram-positive anaerobic cocci (GPAC) is very rare.

Case report: We present a case of a 38-year-old female with Anaerococcus hydrogenalis bacteremia and infective endocarditis of the native mitral valve. She presented with fever, chills, and abdominal pain. A computed tomographic scan of the abdomen showed splenic abscesses. Blood cultures and broad-range PCR from the splenic abscess sample were negative. Transthoracic echocardiography showed a mobile filamentous structure on the atrial side of the anterior mitral leaflet which was suggestive for infective endocarditis. Karius test (cell-free microbial DNA testing) showed Gram-positive anaerobic cocci Anaerococcus hydrogenalis. She was successfully treated with antibiotics.

Conclusions: In cases of infection with fastidious organisms like GPACs, the use of next-generation sequencing (NGS) can allow the correct identification of culprit pathogens and streamlined treatment.

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来源期刊
GERMS
GERMS INFECTIOUS DISEASES-
CiteScore
2.80
自引率
5.00%
发文量
36
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