猴痘抗病毒药物的临床考虑因素:概述。

IF 2.9 4区 医学 Q2 PHARMACOLOGY & PHARMACY Pharmacology Research & Perspectives Pub Date : 2024-02-01 DOI:10.1002/prp2.1164
Fariba Pourkarim, Taher Entezari-Maleki
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引用次数: 0

摘要

猴痘(mpox)是一种属于正痘病毒科的病毒,可引起人畜共患的传染病,并伴有发病率和外观并发症。因此,具有适当安全性的有效抗病毒药物对于治疗猴痘患者非常重要。迄今为止,美国食品和药物管理局尚未批准用于治疗麻腮风的药物。不过,替考韦利马特、布林昔多韦和西多福韦是治疗水痘的候选疗法。考虑到使用这些药物的安全性问题,我们旨在回顾有关水痘抗病毒药物临床注意事项的证据,以便为临床医生的治疗方法提供指导。根据目前的证据,替考韦瑞(tecovirimat)具有良好的临床疗效、安全性和副作用,可作为水痘的一线治疗药物。
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Clinical considerations on monkeypox antiviral medications: An overview.

Monkeypox (mpox), a virus belonging to the orthopoxvirus family, can cause a zoonotic infectious disease with morbidity and cosmetic complications. Therefore, effective antiviral drugs with appropriate safety profiles are important for the treatment of patients with mpox. To date, there is no FDA-approved drug for the treatment of mpox. However, tecovirimat, brincidofovir, and cidofovir are the candidate therapies for the management of mpox. Given the safety concerns following the use of these medications, we aimed to review evidence on the clinical considerations of mpox antiviral medications that will be useful to guide clinicians in the treatment approach. Based on the current evidence, tecovirimat has favorable clinical efficacy, safety, and side effect profile and it can be considered as first-line treatment for mpox.

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来源期刊
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
5.30
自引率
3.80%
发文量
120
审稿时长
20 weeks
期刊介绍: PR&P is jointly published by the American Society for Pharmacology and Experimental Therapeutics (ASPET), the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy, hypotheses, and data resulting in a successful therapeutic drug); frontiers in translational medicine (drug and target validation for an unmet therapeutic need); pharmacological hypotheses (reviews that are oriented to inform a novel hypothesis); and replication studies (work that refutes key findings [failed replication] and work that validates key findings). PR&P publishes papers submitted directly to the journal and those referred from the journals of ASPET and the BPS
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