通过有限元建模预测解剖变异和植入物位置对生物椎间盘植入物性能的影响

IF 3.4 3区 医学 Q1 ORTHOPEDICS JOR Spine Pub Date : 2023-12-27 DOI:10.1002/jsp2.1307
Maho Koga, Byumsu Kim, Marianne Lintz, Sertaç Kirnaz, Jacob L. Goldberg, Ibrahim Hussain, Branden Medary, Kathleen N. Meyers, Suzanne A. Maher, Roger Härtl, Lawrence J. Bonassar
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引用次数: 0

摘要

背景组织工程椎间盘(TE-IVD)结构是治疗椎间盘退行性疾病的一种极具吸引力的疗法,以前曾在大型和小型动物模型中进行过体内研究。脊柱的机械环境具有明显的挑战性,部分原因是其复杂的解剖结构,植入物可能需要额外的机械支撑,以避免在植入初期出现故障。因此,设计合适的支撑植入物需要严格的验证。 方法 我们创建了一个有限元模型来模拟 IVD 骨架在猪颈椎解剖结构压缩下的行为,使用动物模型验证了有限元模型,并预测了植入物位置和运动节段椎体角度对植入物行为的影响。具体来说,我们测试了上椎体的解剖定位和植入物的位置。我们分析了相应的应力和应变分布。 结果 结果表明,猪颈椎的解剖几何形状导致应力和应变集中在笼的后侧。尽管植入物具有优异的机械性能,但这种应力集中与体内报告的笼失效位置有关。此外,研究还发现保持架的放置位置会对移位产生深远影响,而上椎体的角度则会影响保持架的应力集中。 结论 该模型既可用于指导手术过程,也可为未来的骨架设计提供启示,而且无需使用体内动物模型也可采用该模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants

Background

Tissue-engineered intervertebral disc (TE-IVD) constructs are an attractive therapy for treating degenerative disc disease and have previously been investigated in vivo in both large and small animal models. The mechanical environment of the spine is notably challenging, in part due to its complex anatomy, and implants may require additional mechanical support to avoid failure in the early stages of implantation. As such, the design of suitable support implants requires rigorous validation.

Methods

We created a FE model to simulate the behavior of the IVD cages under compression specific to the anatomy of the porcine cervical spine, validated the FE model using an animal model, and predicted the effects of implant location and vertebral angle of the motion segment on implant behavior. Specifically, we tested anatomical positioning of the superior vertebra and placement of the implant. We analyzed corresponding stress and strain distributions.

Results

Results demonstrated that the anatomical geometry of the porcine cervical spine led to concentrated stress and strain on the posterior side of the cage. This stress concentration was associated with the location of failure of the cages reported in vivo, despite superior mechanical properties of the implant. Furthermore, placement of the cage was found to have profound effects on migration, while the angle of the superior vertebra affected stress concentration of the cage.

Conclusions

This model can be utilized both to inform surgical procedures and provide insight on future cage designs and can be adopted to models without the use of in vivo animal models.

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来源期刊
JOR Spine
JOR Spine ORTHOPEDICS-
CiteScore
6.40
自引率
18.90%
发文量
42
审稿时长
10 weeks
期刊最新文献
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