[通过靶向红细胞核因子 2 相关因子 2 信号通路用作抗衰老剂的中药]。

Q3 Medicine 生理学报 Pub Date : 2023-12-25

Jia-Yi Xu, Liang-Wen Yan, Shen-Kang Tang, Peng-Fei Liu

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引用次数: 0

摘要

氧化还原平衡失衡是衰老的一个主要特征，也是各种衰老相关疾病的发病机理之一。作为氧化还原平衡的调控枢纽，核因子红细胞2相关因子2（NRF2）可通过激活多种抗氧化酶的转录来减轻氧化应激。中国是传统中医药的发源地，数千年来，传统中医药一直被广泛用作药物。最近，中药作为抗衰老药物引起了广泛关注。本文以NRF2信号通路为重点，总结了各种抗衰老中药与NRF2信号通路的相关性，并探讨了中药通过靶向NRF2信号网络延缓衰老过程的共同关键机制。

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[Traditional Chinese medicine used as anti-aging agent by targeting nuclear factor erythroid 2-related factor 2 signaling pathway].

The imbalance of redox homeostasis is a major characteristic of aging and contributes to the pathogenesis of various aging-related diseases. As a regulatory hub of redox homeostasis, nuclear factor erythroid 2-related factor 2 (NRF2) can attenuate oxidative stress by activating the transcription of many antioxidant enzymes. China is the birthplace of traditional Chinese medicine (TCM) which has been wildly used as medicine for thousands of years. Recently, TCM as anti-aging medicine has attracted enormous attention. Focusing on the NRF2 signaling pathway, this paper summarizes the correlation between various anti-aging TCM and the NRF2 signaling, and discusses the common key mechanisms by which TCM slows the aging process by targeting the NRF2 signaling network.

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.