杂环核吡嗪及其衍生物的多种生物活性综述：研究人员的一把钥匙

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2023-12-27 DOI:10.2174/0115701786273932230927062616

Shilpi Pathak, Neetu Agrawal, Sonam Gaur

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引用次数: 0

摘要

:吡嗪属于 1，4-二嗪家族，是一类重要的杂环化合物。各种吡嗪衍生物已被生产并成功确认为具有各种药理活性（如抗炎、抗结核、抗癌、抗菌和神经活性）的药物，其中一些已成为全球临床上常用的药物。本综述对具有不同药理活性的吡嗪衍生物进行了调查。从研究化合物的绝对数量和各种生物活性的范围来看，以吡嗪为基础的潜在药物类别增长迅速。此外，这种支架还具有很大的潜力，药物化学家应该对其进行研究，以创造新的潜在候选药物。

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A Review on Diverse Biological Activity of Heterocyclic Nucleus Pyrazine and its Derivatives: A Key for the Researchers

: Pyrazine belongs to the 1, 4-diazines family, which is a significant class of heterocyclic compounds. Various pyrazine derivatives have been produced and successfully confirmed as medicines with various pharmacological activities like anti-inflammatory, antitubercular, anticancer, antibacterial, and neurological activity, with some of them becoming clinically utilized pharmaceuticals globally. This review includes a survey on pyrazine derivatives possessing different pharmacological activities. The class of pyrazine-based potential medications has grown rapidly in terms of both the absolute quantity of studied compounds and the range of various biological activities. Additionally, there is a lot of potential for this scaffold, which medicinal chemists ought to investigate for the creation of novel potential drug candidates.

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.