Ravi K. Mittal, Raghav Mishra, Vikram Sharma, Isha Mishra
{"title":"1,3,4-噻二唑:药物发现的多功能支架","authors":"Ravi K. Mittal, Raghav Mishra, Vikram Sharma, Isha Mishra","doi":"10.2174/0115701786274678231124101033","DOIUrl":null,"url":null,"abstract":":: 1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure, highlighting its relevance and efficacy in pharmaceutical research and development. The key objective of this comprehensive review is to provide an understandable overview of the chemistry and diverse pharmacological activities associated with 1,3,4-thiadiazole compounds. The manuscript was compiled by conducting a thorough literature review, which included an in-depth analysis of globally esteemed scientific research databases. The remarkable chemical characteristics and diverse pharmacological impacts of 1,3,4-Thiadiazole highlight its significant potential as a structural scaffold for the development of novel therapeutic substances. Based on the information available on synthetic molecules that incorporate the 1,3,4-thiadiazole framework and their wide range of uses, it is reasonable to expect significant advancements in the near future and the possibility of employing these compounds in different domains.","PeriodicalId":18116,"journal":{"name":"Letters in Organic Chemistry","volume":"22 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1,3,4-Thiadiazole: A Versatile Scaffold for Drug Discovery\",\"authors\":\"Ravi K. Mittal, Raghav Mishra, Vikram Sharma, Isha Mishra\",\"doi\":\"10.2174/0115701786274678231124101033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\":: 1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure, highlighting its relevance and efficacy in pharmaceutical research and development. The key objective of this comprehensive review is to provide an understandable overview of the chemistry and diverse pharmacological activities associated with 1,3,4-thiadiazole compounds. The manuscript was compiled by conducting a thorough literature review, which included an in-depth analysis of globally esteemed scientific research databases. The remarkable chemical characteristics and diverse pharmacological impacts of 1,3,4-Thiadiazole highlight its significant potential as a structural scaffold for the development of novel therapeutic substances. Based on the information available on synthetic molecules that incorporate the 1,3,4-thiadiazole framework and their wide range of uses, it is reasonable to expect significant advancements in the near future and the possibility of employing these compounds in different domains.\",\"PeriodicalId\":18116,\"journal\":{\"name\":\"Letters in Organic Chemistry\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-12-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Letters in Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0115701786274678231124101033\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0115701786274678231124101033","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
1,3,4-Thiadiazole: A Versatile Scaffold for Drug Discovery
:: 1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure, highlighting its relevance and efficacy in pharmaceutical research and development. The key objective of this comprehensive review is to provide an understandable overview of the chemistry and diverse pharmacological activities associated with 1,3,4-thiadiazole compounds. The manuscript was compiled by conducting a thorough literature review, which included an in-depth analysis of globally esteemed scientific research databases. The remarkable chemical characteristics and diverse pharmacological impacts of 1,3,4-Thiadiazole highlight its significant potential as a structural scaffold for the development of novel therapeutic substances. Based on the information available on synthetic molecules that incorporate the 1,3,4-thiadiazole framework and their wide range of uses, it is reasonable to expect significant advancements in the near future and the possibility of employing these compounds in different domains.
期刊介绍:
Aims & Scope
Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
The journal is an essential reading for all organic chemists belonging to both academia and industry.