晚期恶性黑色素瘤患者肝转移的局部治疗:病例报告

IF 1.4 4区 医学 Q4 ONCOLOGY Journal of cancer research and therapeutics Pub Date : 2023-12-28 DOI:10.4103/jcrt.jcrt_394_22
Hongxi Hong, Lujun Shen, Hongtong Tan, Ying Wu, Ying Liu, Weijun Fan
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摘要

黑色素瘤是一种致命的恶性肿瘤,转移率很高。黑色素瘤的肝转移总是与对免疫疗法不敏感和预后不良有关。然而,冷冻消融术被认为可以刺激体内的抗肿瘤免疫反应,与免疫疗法相结合可以改善对这种疾病的治疗反应。在此,我们介绍了一名 79 岁女性患者的病例,她患有 BRAF(B-Raf 原癌基因)野生型黑色素瘤,后来出现了肝转移。患者静脉注射了抗程序性细胞死亡 1 抗体,但疗效不佳,随后接受了免疫疗法联合冷冻消融治疗,取得了部分反应。然而,在第二次冷冻消融术后,患者因害怕出血而拒绝进一步治疗。因此,患者只接受了免疫治疗,结果导致病情恶化。该报告表明,在治疗 BRAF 野生型黑色素瘤患者的肝转移灶时,有必要考虑免疫疗法加冷冻消融术。
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Local treatment of liver metastasis in a patient with advanced malignant melanoma: A case report

Melanoma is a fatal malignant tumor with a high rate of metastasis. Liver metastasis of melanoma is always associated with insensitivity to immunotherapy and a poor prognosis. However, the combination of cryoablation, which is believed to stimulate the antitumor immune response in the body, with immunotherapy can improve the therapeutic response to this condition. Herein, we present the case of a 79-year-old woman with BRAF (B-Raf proto-oncogene) wild-type melanoma who later developed liver metastasis. The patient received intravenous antiprogrammed cell death 1 antibody, which showed poor efficacy, and subsequent treatment with immunotherapy combined with cryoablation yielded a partial response. However, after the second cryoablation, the patient refused further treatment due to a fear of bleeding. Therefore, only immunotherapy was provided, which resulted in disease progression. This report demonstrates the need to consider immunotherapy plus cryoablation for the treatment of liver metastases in patients with BRAF wild-type melanoma.

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来源期刊
CiteScore
1.80
自引率
15.40%
发文量
299
审稿时长
6 months
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Medical oncology, radiation oncology, medical imaging, radiation protection, non-ionising radiation, radiobiology. Articles with clinical interest and implications will be given preference.
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