含托烷化合物生物活性的专利审查。

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL Expert Opinion on Therapeutic Patents Pub Date : 2023-12-01 Epub Date: 2024-01-15 DOI:10.1080/13543776.2023.2299349
Thoraya A Farghaly, Ghada S Masaret, Hanan Gaber Abdulwahab
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引用次数: 0

摘要

简介:从托烷中提取的药物历来在药物治疗中发挥着重要作用。天然和合成的托烷衍生物可用于治疗各种病症。以托烷为基础的药物主要包括:具有解痉作用的丁溴东莨菪碱、用作眼药水的阿托品、具有抗病毒作用的马拉维若、用作膀胱过度活动症解痉剂的氯化曲司铵以及支气管扩张剂异丙托溴铵:我们汇编了截至 2023 年与含托烷物质的生物活性有关的专利,并根据其表现出的特定生物活性类型进行了分类。我们使用 ScienceFinder、ScienceDirect 和 Patent Guru 搜索了截至 2023 年的科学文章和专利文献:学术界和工业界的制药研究人员对托烷衍生物表现出了浓厚的兴趣。尽管如此,仍有大量工作要做。在学术界和工业界的共同努力下,有必要采取重点突出的方法,探索和推进含托烷的天然和合成生物活性分子。利用药物和合成化学方面的现代技术和工艺,包括高通量筛选、药物再利用和生物技术工程,有可能揭示新的可能性,并加快以托烷为基础的创新药物的发现过程。
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The patent review of the biological activity of tropane containing compounds.

Introduction: Tropane-derived medications have historically played a substantial role in pharmacotherapy. Both natural and synthetic derivatives of tropane find application in addressing diverse medical conditions. Prominent examples of tropane-based drugs include hyoscine butylbromide, recognized for its antispasmodic properties, atropine, employed as a mydriatic, maraviroc, known for its antiviral effects. trospium chloride, utilized as a spasmolytic for overactive bladder, and ipratropium, a bronchodilator.

Areas covered: We compiled patents pertaining to the biological activity of substances containing tropane up to the year 2023 and categorized them according to the specific type of biological activity they exhibit. ScienceFinder, ScienceDirect, and Patent Guru were used to search for scientific articles and patent literature up to 2023.

Expert opinion: Pharmaceutical researchers in academic and industrial settings have shown considerable interest in tropane derivatives. Despite this, there remains a substantial amount of work to be undertaken. A focused approach is warranted for the exploration and advancement of both natural and synthetic bioactive molecules containing tropane, facilitated through collaborative efforts between academia and industry. Leveraging contemporary techniques and technologies in medicinal and synthetic chemistry, including high throughput screening, drug repurposing,and biotechnological engineering, holds the potential to unveil novel possibilities and accelerate the drug discovery process for innovative tropane-based pharmaceuticals.

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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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A patent review of UNC-51-like kinase 1/2 inhibitors (2019-present). Urease inhibitors for the treatment of H. pylori. Menin-MLL protein-protein interaction inhibitors: a patent review (2021-present). Therapeutic compounds targeting interleukin-1 receptor-associated kinase 4 (IRAK4): an updated patent review (2019 to present). A patent review of lactate dehydrogenase inhibitors (2014-present).
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