在小鼠和人类胚胎植入前发育过程中,MicroRNA 在系谱规范中的功能作用证据。

IF 2.5 3区 工程技术 Q2 BIOLOGY Yale Journal of Biology and Medicine Pub Date : 2023-12-29 eCollection Date: 2023-12-01 DOI:10.59249/FOSI4358
Savana Biondic, Sophie Petropoulos
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引用次数: 0

摘要

囊胚的正确形成,包括第一个胚胎细胞系的规范化,是确保胚胎健康发育的必要条件,而且会对辅助生殖技术(ART)的成功产生重大影响。然而,microRNA 在早期发育中的调控作用,尤其是在植入前细胞系规范方面的作用,在很大程度上仍不为人所知。本综述采用跨物种方法,旨在总结 microRNA 在小鼠和人类血统特征的分化和维持过程中的表达动态和功能意义。本综述综合了使用代表上胚层、滋养层和原始内胚层的体外胚胎干细胞模型(分别以幼稚胚胎干细胞、滋养层干细胞和胚外内胚层干细胞为模型)进行的研究结果,以深入了解胚胎中可能发生的情况。此外,还讨论了直接在小鼠和人类胚胎中进行的研究,强调了与干细胞模型的相似之处以及我们在认识上的差距,希望这些研究能促进对这些领域的进一步研究。通过揭示microRNA调控囊胚中细胞系的规范和维持的复杂机制,我们可以利用这些知识进一步优化囊胚等基于干细胞的模型,提高胚胎能力,开发无创胚胎选择方法,从而有可能提高辅助生殖技术的成功率,改善接受生育治疗者的体验。
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Evidence for Functional Roles of MicroRNAs in Lineage Specification During Mouse and Human Preimplantation Development.

Proper formation of the blastocyst, including the specification of the first embryonic cellular lineages, is required to ensure healthy embryo development and can significantly impact the success of assisted reproductive technologies (ARTs). However, the regulatory role of microRNAs in early development, particularly in the context of preimplantation lineage specification, remains largely unknown. Taking a cross-species approach, this review aims to summarize the expression dynamics and functional significance of microRNAs in the differentiation and maintenance of lineage identity in both the mouse and the human. Findings are consolidated from studies conducted using in vitro embryonic stem cell models representing the epiblast, trophectoderm, and primitive endoderm lineages (modeled by naïve embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm stem cells, respectively) to provide insight on what may be occurring in the embryo. Additionally, studies directly conducted in both mouse and human embryos are discussed, emphasizing similarities to the stem cell models and the gaps in our understanding, which will hopefully lead to further investigation of these areas. By unraveling the intricate mechanisms by which microRNAs regulate the specification and maintenance of cellular lineages in the blastocyst, we can leverage this knowledge to further optimize stem cell-based models such as the blastoids, enhance embryo competence, and develop methods of non-invasive embryo selection, which can potentially increase the success rates of assisted reproductive technologies and improve the experiences of those receiving fertility treatments.

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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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