{"title":"年轻发病的 2 型糖尿病和视网膜病变:不良表型的证据","authors":"Soon H Song","doi":"10.1136/bmjdrc-2023-003899","DOIUrl":null,"url":null,"abstract":"The landscape of type 2 diabetes (T2D) has changed with an increasing number of people being diagnosed under age 40 years. The principal concern with young-onset T2D is the early development of complications, with associated morbidity and premature mortality. In view of the potential impact on the working-age population and the associated personal, societal and economic ramifications, it is important to understand the factors that drive the pathogenesis of these complications in order to mitigate or prevent their occurrence. Few studies have investigated the impact of young-onset T2D on microvascular disease such as retinopathy. As one of the leading causes of blindness and visual impairment in adults under age 40 years,1 this is a feared complication among people with diabetes and merits further investigation. In this issue of the journal, Tibballs et al 2 report that young adult-onset T2D, diagnosed between the ages of 18 and 39 years and constituting 10% of the overall population with T2D, had a higher burden of retinopathy and a greater risk of developing this complication, including severe retinal disease, compared with those diagnosed with T2D later in life. Young-onset male subjects were particularly susceptible to this complication. Despite receiving more intensive diabetes treatment, including insulin, the young-onset cohort exhibited more rapid deterioration in glycemic control. Compared with females with T2D, the young-onset males had higher HbA1c at diagnosis and this difference in glycemic control persisted …","PeriodicalId":9151,"journal":{"name":"BMJ Open Diabetes Research & Care","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Young-onset type 2 diabetes and retinopathy: evidence of an adverse phenotype\",\"authors\":\"Soon H Song\",\"doi\":\"10.1136/bmjdrc-2023-003899\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The landscape of type 2 diabetes (T2D) has changed with an increasing number of people being diagnosed under age 40 years. The principal concern with young-onset T2D is the early development of complications, with associated morbidity and premature mortality. In view of the potential impact on the working-age population and the associated personal, societal and economic ramifications, it is important to understand the factors that drive the pathogenesis of these complications in order to mitigate or prevent their occurrence. Few studies have investigated the impact of young-onset T2D on microvascular disease such as retinopathy. As one of the leading causes of blindness and visual impairment in adults under age 40 years,1 this is a feared complication among people with diabetes and merits further investigation. In this issue of the journal, Tibballs et al 2 report that young adult-onset T2D, diagnosed between the ages of 18 and 39 years and constituting 10% of the overall population with T2D, had a higher burden of retinopathy and a greater risk of developing this complication, including severe retinal disease, compared with those diagnosed with T2D later in life. Young-onset male subjects were particularly susceptible to this complication. Despite receiving more intensive diabetes treatment, including insulin, the young-onset cohort exhibited more rapid deterioration in glycemic control. Compared with females with T2D, the young-onset males had higher HbA1c at diagnosis and this difference in glycemic control persisted …\",\"PeriodicalId\":9151,\"journal\":{\"name\":\"BMJ Open Diabetes Research & Care\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMJ Open Diabetes Research & Care\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/bmjdrc-2023-003899\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Open Diabetes Research & Care","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bmjdrc-2023-003899","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Young-onset type 2 diabetes and retinopathy: evidence of an adverse phenotype
The landscape of type 2 diabetes (T2D) has changed with an increasing number of people being diagnosed under age 40 years. The principal concern with young-onset T2D is the early development of complications, with associated morbidity and premature mortality. In view of the potential impact on the working-age population and the associated personal, societal and economic ramifications, it is important to understand the factors that drive the pathogenesis of these complications in order to mitigate or prevent their occurrence. Few studies have investigated the impact of young-onset T2D on microvascular disease such as retinopathy. As one of the leading causes of blindness and visual impairment in adults under age 40 years,1 this is a feared complication among people with diabetes and merits further investigation. In this issue of the journal, Tibballs et al 2 report that young adult-onset T2D, diagnosed between the ages of 18 and 39 years and constituting 10% of the overall population with T2D, had a higher burden of retinopathy and a greater risk of developing this complication, including severe retinal disease, compared with those diagnosed with T2D later in life. Young-onset male subjects were particularly susceptible to this complication. Despite receiving more intensive diabetes treatment, including insulin, the young-onset cohort exhibited more rapid deterioration in glycemic control. Compared with females with T2D, the young-onset males had higher HbA1c at diagnosis and this difference in glycemic control persisted …
期刊介绍:
BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of
high-quality — and evidence-based — original research articles.