Hamed Moradi, Rajat Vashistha, Kieran O’Brien, Amanda Hammond, Viktor Vegh, David Reutens
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引用次数: 0
摘要
在参数 PET 中,动力学参数是从动态 PET 图像中提取的。由于扫描时间长且需要动脉输入函数(AIF),这种方法在临床实践中并不常用。为了解决这些局限性,我们设计了一种 18F- 氟脱氧葡萄糖(18F-FDG)三重注射动态 PET 方案,使用标准视野 PET 扫描仪进行脑成像,使用 24 分钟成像窗口,并使用左心室上方感兴趣区的测量结果模拟输入函数。为了在 6 名健康参与者中测试该方案,我们检查了使用双组织室模型生成的基于体素的大脑动力学参数图的质量,并将估计参数值与之前公布的值进行了比较。我们还利用 36 分钟验证成像窗口的数据,比较了(1)建模的 AIF 与验证窗口中测量的输入函数;以及(2)使用短成像窗口中的参数估算值计算的净流入率($$K_{i}$$)与验证窗口中使用 Patlak 分析获得的净流入率。与验证窗口测得的 AIF 相比,短成像窗口估计的输入函数的平均曲线下面积误差为 9%。短成像窗口和验证成像窗口估计的 $$K_{i}$ 之间的体素相关性超过 0.95。所提出的 24 分钟三重注射方案可实现参数化 18F-FDG 神经成像,并使用标准视野 PET 扫描仪从心脏图像无创估计 AIF。
A short 18F-FDG imaging window triple injection neuroimaging protocol for parametric mapping in PET
In parametric PET, kinetic parameters are extracted from dynamic PET images. It is not commonly used in clinical practice because of long scan times and the requirement for an arterial input function (AIF). To address these limitations, we designed an 18F-fluorodeoxyglucose (18F-FDG) triple injection dynamic PET protocol for brain imaging with a standard field of view PET scanner using a 24-min imaging window and an input function modeled using measurements from a region of interest placed over the left ventricle. To test the protocol in 6 healthy participants, we examined the quality of voxel-based maps of kinetic parameters in the brain generated using the two-tissue compartment model and compared estimated parameter values with previously published values. We also utilized data from a 36-min validation imaging window to compare (1) the modeled AIF against the input function measured in the validation window; and (2) the net influx rate ( $$K_{i}$$ ) computed using parameter estimates from the short imaging window against the net influx rate obtained using Patlak analysis in the validation window. Compared to the AIF measured in the validation window, the input function estimated from the short imaging window achieved a mean area under the curve error of 9%. The voxel-wise Pearson’s correlation between $$K_{i}$$ estimates from the short imaging window and the validation imaging window exceeded 0.95. The proposed 24-min triple injection protocol enables parametric 18F-FDG neuroimaging with noninvasive estimation of the AIF from cardiac images using a standard field of view PET scanner.
EJNMMI ResearchRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING&nb-
CiteScore
5.90
自引率
3.10%
发文量
72
审稿时长
13 weeks
期刊介绍:
EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies.
The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy.