[更新心脏肿瘤学:免疫检查点抑制剂疗法]。

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Herz Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI:10.1007/s00059-023-05228-9
Lars Michel, Tienush Rassaf
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引用次数: 0

摘要

在德国,心血管疾病和癌症是最常见的死亡原因。癌症治疗会对心血管产生严重的副作用,因此成为这两种疾病之间的联系。心肿瘤学的重点是对癌症治疗引起的心血管并发症进行最佳预防、诊断和治疗。对于肿瘤心脏病学来说,适应新的肿瘤治疗方式的不断发展至关重要,因为新的肿瘤治疗方式具有以前未知的心血管副作用。免疫检查点抑制剂(ICI)疗法就是这样一种新的治疗方式,因其卓越的肿瘤疗效而被视为近十年来最重要的肿瘤学里程碑;然而,该疗法的日益广泛使用却揭示了多种心血管副作用的高风险,以及高发病率和死亡率,因此,对受影响患者的心肿瘤学护理尤为重要。本综述总结了 ICI 治疗心血管副作用的病理生理学、发病率、诊断和治疗的科学和临床现状。
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[Update cardio-oncology : Immune checkpoint inhibitor therapy].

Cardiovascular diseases and cancer are the most common causes of death in Germany. Cancer treatment can lead to significant cardiovascular side effects and thus form a link between the two disease groups. The focus of cardio-oncology is on the best possible prevention, diagnostics and treatment of cardiovascular complications caused by cancer treatment. It is crucial for cardio-oncology to adapt to the continuous development of new forms of oncological treatment with previously unknown cardiovascular side effects. One such new form of treatment is immune checkpoint inhibitor (ICI) therapy, which is regarded as the most important oncological milestone of the last decade due to its excellent oncological efficacy; however, the growing use has revealed a high risk of diverse cardiovascular side effects with high morbidity and mortality, so that cardio-oncological care of affected patients is of particular importance. This review summarizes the current scientific and clinical state of the pathophysiology, incidence, diagnosis and treatment of cardiovascular side effects of ICI therapy.

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来源期刊
Herz
Herz 医学-心血管系统
CiteScore
3.00
自引率
5.90%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Herz is the high-level journal for further education for all physicians interested in cardiology. The individual issues of the journal each deal with specific topics and comprise review articles in English and German written by competent and esteemed authors. They provide up-to-date and comprehensive information concerning the speciality dealt with in the issue. Due to the fact that all relevant aspects of the pertinent topic of an issue are considered, an overview of the current status and progress in cardiology is presented. Reviews and original articles round off the spectrum of information provided.
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