肺肉样瘤病和免疫介导的坏死性肌病：一种不常见的巧合。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-01

Ana Martins, Sofia Pimenta, Frederico Rajão Martins, Beatriz Samões, Rafaela Nicolau, Eva Mariz, Lúcia Costa

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引用次数: 0

摘要

简介：免疫介导的坏死性肌病（IMNM）的特征是急性或亚急性、严重的近端肌无力和肌纤维坏死，肌肉活检可观察到极少量的炎性细胞浸润。另一方面，肉样瘤病的特点是出现非酪氨酸肉芽肿，可在多个器官中发展：病例报告：我们介绍了一例独特的病例，患者是一名 49 岁女性，既往无病史，罕见地同时患上了 IMNM 和肺肉样瘤病。通过皮质类固醇和利妥昔单抗联合治疗以及康复计划，该病症获得了成功：讨论：此前仅有两例病例报告了这种关联。讨论：此前仅有两篇病例报告了这种关联，这凸显了进一步研究肉样瘤病与其他形式的炎症性肌病之间关联的重要性。

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Pulmonary sarcoidosis and immune-mediated necrotizing myopathy: an uncommon coincidence.

Introduction: Immune-mediated necrotizing myopathy (IMNM) is characterized by acute or subacute, severe proximal muscle weakness and myofiber necrosis with minimal inflammatory cell infiltrate observed on muscle biopsy. On the other hand, sarcoidosis is characterised by the presence of non-caseating granulomas that can develop in several organs.

Case report: We present the unique case of a 49-year-old woman, with no previous medical history, who had a rare concomitant occurrence of IMNM and pulmonary sarcoidosis. This condition was successfully treated with a combination of corticosteroids and rituximab along with rehabilitation program.

Discussion: This association has been reported in only two previous case reports. This highlights the importance of further research on the connection between sarcoidosis and other forms of inflammatory myopathies.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.