新陈代谢操作系统的安全性、可扩展性和冗余性

Samuel T. King
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摘要

1 型糖尿病(T1D)患者失去了自然产生胰岛素的能力。为了弥补这一缺陷,他们需要注射合成胰岛素。注射胰岛素的一种常见方式是通过自动胰岛素输送系统,该系统使用传感器监测患者的新陈代谢状态,并使用胰岛素泵设备调节胰岛素以适应新陈代谢。在本文中,我们介绍了新陈代谢操作系统,这是一种全新的自动胰岛素输送系统,我们采用安全第一的原则从头开始设计该系统。从架构的角度来看,我们运用分离原则简化了核心系统,并将非关键功能与核心闭环算法隔离开来。从算法角度来看,我们评估了胰岛素技术的发展趋势,并根据最新技术制定了简单而有效的算法。从安全角度来看,我们建立了多层冗余,以确保使用我们系统的人的安全。从根本上说,本文是一篇关于构建和运行胰岛素自动输送系统的实际经验的论文。我们报告了根据与一个使用我们系统的人的合作经验所做的评估。我们的评估结果表明,采用安全第一原则从头构建的胰岛素自动给药系统仍能帮助有效管理 T1。我们的源代码是开源的,可在 GitHub 上获取(链接省略)。
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Security, extensibility, and redundancy in the Metabolic Operating System
People living with Type 1 Diabetes (T1D) lose the ability to produce insulin naturally. To compensate, they inject synthetic insulin. One common way to inject insulin is through automated insulin delivery systems, which use sensors to monitor their metabolic state and an insulin pump device to adjust insulin to adapt. In this paper, we present the Metabolic Operating System, a new automated insulin delivery system that we designed from the ground up using security first principles. From an architecture perspective, we apply separation principles to simplify the core system and isolate non-critical functionality from the core closed-loop algorithm. From an algorithmic perspective, we evaluate trends in insulin technology and formulate a simple, but effective, algorithm given the state-of-the-art. From a safety perspective, we build in multiple layers of redundancy to ensure that the person using our system remains safe. Fundamentally, this paper is a paper on real-world experiences building and running an automated insulin delivery system. We report on the design iterations we make based on experiences working with one individual using our system. Our evaluation shows that an automated insulin delivery system built from the ground up using security first principles can still help manage T1D effectively. Our source code is open source and available on GitHub (link omitted).
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