morusin的抗结核活性：白桑中一种有前途的黄酮类化合物。

IF 3.4 3区医学 Q2 INFECTIOUS DISEASES International Journal of Tuberculosis and Lung Disease Pub Date : 2024-01-01 DOI:10.5588/ijtld.23.0224

K Yildirim, S Bozkurt, H H Basibuyuk, A Y Coban

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引用次数: 0

摘要

背景：从古至今，结核病一直是一个重大的公共卫生问题。每年，由于耐药性问题日益严重，因此有必要发现治疗结核病的新药物和药物前体。Morusin 是白桑树（Morus alba L.）树皮中发现的一种重要黄酮，具有抗氧化、抗菌、抗肿瘤、抗炎和抗过敏活性。设计：在 H37Ra（美国类型培养物保藏中心 [ATCC] 25177）、H37Rv（ATCC 27294）、ATCC 35822（耐异烟肼 [INH]）、ATCC 35838（耐利福平 [RIF]）和 ATCC 35820（耐链霉素 [SM]）标准菌株上测试吗菌素的抗结核功效，并使用硝酸还原酶测定法（NRA）确定其功效。结果：莫鲁信的最低抑菌浓度（MIC）为 53.83-"0.21 δg/ml。H37Ra（ATCC 25177）、H37Rv（ATCC 27294）和ATCC 35838（RIF耐药）菌株的MIC为6.72 μg/ml，ATCC 35822（INH耐药）和ATCC 35820（SM耐药）菌株的MIC为13.45 μg/ml。结论：要将吗丁啉视为治疗结核病的可行替代药物或先导药物，必须对其作用机制进行详尽研究，并利用临床分离菌株进行体外研究。

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Anti-tuberculosis activity of morusin: a promising flavonoid from white mulberry.

BACKGROUND: TB has remained a significant public health concern from historical times to the present day. Each year, growing drug resistance problems necessitate the discovery of new drugs and drug precursors for TB treatment. Morusin is an important flavone found in the bark of white mulberry (Morus alba L.) with anti-oxidant, antimicrobial, anti-tumour, anti-inflammatory and antiallergic activity.OBJECTIVE: To determine the anti-TB efficacy of morusin on Mycobacterium tuberculosis strains.DESIGN: Anti-TB efficacy of morusin was tested on H37Ra (American Type Culture Collection [ATCC] 25177), H37Rv (ATCC 27294), ATCC 35822 (isoniazid [INH] resistant), ATCC 35838 (rifampicin [RIF] resistant), and ATCC 35820 (streptomycin [SM] resistant) standard strains and its efficacy was determined using nitrate reductase assay (NRA).RESULTS: The minimum inhibitory concentration (MIC) of morusin was tested in the range of 53.83â-"0.21 Î¼g/ml. The MIC for H37Ra (ATCC 25177), H37Rv (ATCC 27294) and ATCC 35838 (RIF-resistant) strains were found to be 6.72 Î¼g/ml, and this was 13.45 Î¼g/ml for the ATCC 35822 (INHresistant) and ATCC 35820 (SM-resistant) strains.CONCLUSION: To consider morusin as a viable alternative or precursor drug for TB treatment, it is imperative to conduct an exhaustive examination of its mechanism of action and conduct in vitro studies using clinical isolates.

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来源期刊

International Journal of Tuberculosis and Lung Disease 医学-传染病学

CiteScore

4.90

自引率

20.00%

发文量

266

审稿时长

2 months

期刊介绍： The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.