人参多糖和皂苷的抗弓形虫特性

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL Pharmazie Pub Date : 2023-12-04 DOI:10.1691/ph.2023.3622

Weifeng Yan, Zhe Cui, Wenxin Li, Xin An, Xu Cheng, Sihong Wang, Chunmei Jin

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引用次数: 0

摘要

由于出现了高毒性，因此需要新的抗弓形虫药物。人参多糖和皂苷可用于治疗弓形虫的复制，试图确定人参的药用价值是否得到药理作用的支持。研究人员对人参多糖和皂苷的体外和体内抗弓形虫活性进行了检测。研究结果表明，与未经处理的对照组小鼠相比，摄入人参多糖和皂苷后，感染弓形虫小鼠的存活时间和存活率均有所增加。用人参皂苷治疗的小鼠存活率最高，达 83.3%，尤其是用人参多糖治疗的小鼠脾肿大现象明显减少（P < 0.05）。因此，人参多糖和人参皂苷在抗弓形虫治疗中具有潜在的应用价值。

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Anti- Toxoplasma gondii Properties of Ginseng polysaccharides and saponins.

New anti- Toxoplasma gondii agents are in demand due to the emergence of high toxicity. Ginseng polysaccharides and saponins can be used to treat the replication of Toxoplasma gondii in an attempt to determine whether the medicinal uses of ginseng are supported by pharmacological effects. Anti- Toxoplasma gondii activities of ginseng polysaccharides and saponins were examined in vitro and in vivo. The findings are the survival time and rate of Toxoplasma gondii infected mice after the intake of the total polysaccharides and saponins increased compared to untreated control mice. The survival rate of mice treated with ginseng saponins was the highest at 83.3%, the phenomenon of splenomegaly of mice was decreased especially ( p < 0.05) treated with ginseng polysaccharides. Accordingly, ginseng polysaccharides and saponins have a potential application in anti-Toxoplasma gondii treatments.

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来源期刊

Pharmazie 医学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

1.2 months

期刊介绍： The journal DiePharmazie publishs reviews, experimental studies, letters to the editor, as well as book reviews. The following fields of pharmacy are covered: Pharmaceutical and medicinal chemistry; Pharmaceutical analysis and drug control; Pharmaceutical technolgy; Biopharmacy (biopharmaceutics, pharmacokinetics, biotransformation); Experimental and clinical pharmacology; Pharmaceutical biology (pharmacognosy); Clinical pharmacy; History of pharmacy.