Zeynep Akcaoglu, Thomas Vaessen, Eva Velthorst, Ginette Lafit, Robin Achterhof, Barnaby Nelson, Patrick McGorry, Frederike Schirmbeck, Craig Morgan, Jessica Hartmann, Mark van der Gaag, Lieuwe de Haan, Lucia Valmaggia, Philip McGuire, Matthew Kempton, Henrietta Steinhart, Annelie Klippel, Wolfgang Viechtbauer, Tim Batink, Ruud van Winkel, Thérèse van Amelsvoort, Machteld Marcelis, Evelyne van Aubel, Ulrich Reininghaus, Inez Myin-Germeys
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引用次数: 0
摘要
背景:在精神病的早期阶段,精神体验(PEs)和社会隔离(SI)似乎是相关的,但两者之间的时间动态并不清楚。迄今为止的文献表明,精神体验的瞬间增加会导致社交退缩,而社交退缩又会在下一个时间点引发精神体验,尤其是当社交退缩与痛苦增加相关时,这两者之间会形成一个自我循环。本研究调查了 SI 与 PE 之间的日常生活时间关联,以及 SI 相关和一般情感困扰在精神病临床高风险(CHR)人群中的作用:我们在 137 名临床高危人群中采用了经验取样法。我们使用时滞线性混合效应模型分析了SI、PE和痛苦之间的关联:结果:SI 无法预测 PE 的下一时刻波动,反之亦然。此外,虽然与 SI 相关的困扰不能预测随后的 PE,但 SI 期间的一般情感困扰却能有力地预测下一时刻的 PE:我们的研究结果表明,SI 和 PE 在瞬间到瞬间的水平上没有直接关系,但单独的负面情绪状态确实会增加 PE 的风险。这些发现凸显了情绪健康在早期精神病发展过程中的作用。
The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis.
Background: Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in PEs lead to social withdrawal, which, subsequently, triggers PEs at a next point in time, especially when SI is associated with increased distress. The current study investigated the daily-life temporal associations between SI and PEs, as well as the role of SI-related and general affective distress in individuals at clinical high risk (CHR) for psychosis.
Methods: We used experience sampling methodology in a sample of 137 CHR participants. We analyzed the association between SI, PEs, and distress using time-lagged linear mixed-effects models.
Results: SI did not predict next-moment fluctuations in PEs, or vice versa. Furthermore, although SI-related distress was not predictive of subsequent PEs, general affective distress during SI was a robust predictor of next-moment PEs.
Conclusions: Our results suggest that SI and PEs are not directly related on a moment-to-moment level, but a negative emotional state when alone does contribute to the risk of PEs. These findings highlight the role of affective wellbeing during early-stage psychosis development.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.