{"title":"P2Y6 受体在心血管疾病和炎症性疾病发病机制中的作用","authors":"Kazuhiro Nishiyama","doi":"10.1016/j.jphs.2024.01.003","DOIUrl":null,"url":null,"abstract":"<div><p>The purinergic receptor P2Y<sub>6</sub> receptor (P2Y<sub>6</sub>R) is a member of the G protein-coupled receptors (GPCR) family. P2Y<sub>6</sub>R is widely expressed in various cell types and plays a critical role in physiological processes, where it is activated by extracellular uridine diphosphate (UDP) and mobilizes Ca<sup>2+</sup> via the G<sub>αq/11</sub> protein pathway. We have recently discovered the pathophysiological role of P2Y<sub>6</sub>R in cardiovascular and inflammatory diseases, including inflammatory bowel disease and non-alcoholic fatty liver disease. Furthermore, we uncovered the redox-dependent internalization of P2Y<sub>6</sub>R. In this review, we provide a comprehensive overview of the pathophysiological activity of P2Y<sub>6</sub>R in cardiovascular and inflammatory diseases. Additionally, we discuss the concept of atypical internalization control of GPCRs, which may be applied in the prevention and treatment of intestinal inflammation and cardiovascular remodeling.</p></div>","PeriodicalId":16786,"journal":{"name":"Journal of pharmacological sciences","volume":"154 2","pages":"Pages 108-112"},"PeriodicalIF":3.0000,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1347861324000033/pdfft?md5=247fd27157e9f44c7eecbc02e15a9785&pid=1-s2.0-S1347861324000033-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases\",\"authors\":\"Kazuhiro Nishiyama\",\"doi\":\"10.1016/j.jphs.2024.01.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The purinergic receptor P2Y<sub>6</sub> receptor (P2Y<sub>6</sub>R) is a member of the G protein-coupled receptors (GPCR) family. P2Y<sub>6</sub>R is widely expressed in various cell types and plays a critical role in physiological processes, where it is activated by extracellular uridine diphosphate (UDP) and mobilizes Ca<sup>2+</sup> via the G<sub>αq/11</sub> protein pathway. We have recently discovered the pathophysiological role of P2Y<sub>6</sub>R in cardiovascular and inflammatory diseases, including inflammatory bowel disease and non-alcoholic fatty liver disease. Furthermore, we uncovered the redox-dependent internalization of P2Y<sub>6</sub>R. In this review, we provide a comprehensive overview of the pathophysiological activity of P2Y<sub>6</sub>R in cardiovascular and inflammatory diseases. Additionally, we discuss the concept of atypical internalization control of GPCRs, which may be applied in the prevention and treatment of intestinal inflammation and cardiovascular remodeling.</p></div>\",\"PeriodicalId\":16786,\"journal\":{\"name\":\"Journal of pharmacological sciences\",\"volume\":\"154 2\",\"pages\":\"Pages 108-112\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-01-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1347861324000033/pdfft?md5=247fd27157e9f44c7eecbc02e15a9785&pid=1-s2.0-S1347861324000033-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pharmacological sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1347861324000033\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1347861324000033","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases
The purinergic receptor P2Y6 receptor (P2Y6R) is a member of the G protein-coupled receptors (GPCR) family. P2Y6R is widely expressed in various cell types and plays a critical role in physiological processes, where it is activated by extracellular uridine diphosphate (UDP) and mobilizes Ca2+ via the Gαq/11 protein pathway. We have recently discovered the pathophysiological role of P2Y6R in cardiovascular and inflammatory diseases, including inflammatory bowel disease and non-alcoholic fatty liver disease. Furthermore, we uncovered the redox-dependent internalization of P2Y6R. In this review, we provide a comprehensive overview of the pathophysiological activity of P2Y6R in cardiovascular and inflammatory diseases. Additionally, we discuss the concept of atypical internalization control of GPCRs, which may be applied in the prevention and treatment of intestinal inflammation and cardiovascular remodeling.
期刊介绍：
Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.
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