滤泡淋巴瘤的 CAR-T 细胞疗法

IF 2 4区医学 Q3 HEMATOLOGY Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-01-01 DOI:10.4084/mjhid.2024.012

Ugo Testa, F. D'Alo', E. Pelosi, G. Castelli, Giuseppe Leone

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引用次数: 0

摘要

滤泡性淋巴瘤是西欧第二大确诊淋巴瘤。医学的重大进步大大提高了滤泡性淋巴瘤患者的生存率。然而，10%-20%的患者对标准疗法难治，其中大多数会复发。治疗多次复发或难治的滤泡性淋巴瘤患者是一个亟需疗效更强的新疗法的领域。以 CD19 或 CD20 等 B 细胞抗原为靶点的嵌合抗原受体（CAR）-T 细胞疗法正在成为治疗复发/难治滤泡性淋巴瘤患者的有效疗法，特别是对于那些早期复发、对烷化剂和抗 CD20 单克隆抗体难治的患者，这种疗法能使很高比例的患者产生持久反应。

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CAR-T CELL THERAPY FOR FOLLICULAR LYMPHOMAS

Follicular lymphoma is the second most diagnosed lymphoma in Western Europe. Significant advancements have considerably improved the survival of FL patients. However, 10-20% of these patients are refractory to standard treatments, and most of them will relapse. The treatment of follicular lymphoma patients with multiply relapsed or refractory disease represents an area of high-unmet needing new treatments with stronger efficacy. Chimeric antigen receptor (CAR)-T cell therapy targeting B-cell antigens, such as CD19 or CD20, is emerging as an efficacious treatment for R/R follicular lymphoma patients, particularly for those with early relapse and refractory to alkylating agents and to anti-CD20 monoclonal antibodies, resulting in a high rate of durable responses in a high proportion of patients.

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来源期刊

Mediterranean Journal of Hematology and Infectious Diseases Medicine-Hematology

CiteScore

4.20

自引率

6.20%

发文量

113

审稿时长

12 weeks

期刊介绍： Reciprocal interdependence between infectious and hematologic diseases (malignant and non-malignant) is well known. This relationship is particularly evident in Mediterranean countries. Parasitosis as Malaria, Leishmaniosis, B Hookworms, Teniasis, very common in the southeast Mediterranean area, infect about a billion people and manifest prevalently with anemia so that they are usually diagnosed mostly by experienced hematologist on blood or bone marrow smear. On the other hand, infections are also a significant problem in patients affected by hematological malignancies. The blood is the primary vector of HIV infection, which otherwise manifest with symptoms related to a reduction in T lymphocytes. In turn, infections can favor the insurgency of hematological malignancies. The causative relationship between Epstein-Barr virus infection, Helicobacter pylori, hepatitis C virus, HIV and lymphoproliferative diseases is well known.