一名接受醋酸格拉替雷治疗的免疫功能正常患者的急性侵袭性真菌性鼻窦炎病例

IF 1.9 Q2 MEDICINE, GENERAL & INTERNAL Precision and Future Medicine Pub Date : 2023-12-31 DOI:10.23838/pfm.2023.00114
Melanie Hicks, J. Bishop, Brenton T. Bicknell, J. Grayson, B. Woodworth, D. Cho
{"title":"一名接受醋酸格拉替雷治疗的免疫功能正常患者的急性侵袭性真菌性鼻窦炎病例","authors":"Melanie Hicks, J. Bishop, Brenton T. Bicknell, J. Grayson, B. Woodworth, D. Cho","doi":"10.23838/pfm.2023.00114","DOIUrl":null,"url":null,"abstract":"Acute invasive fungal sinusitis (AIFS) is a rapidly progressing, life-threatening infection. The advent of immunomodulatory therapies has expanded the population susceptible to AIFS. In this case report, we describe a patient who defies the conventional profile of AIFS. This 70-year-old woman is immunocompetent and non-diabetic, with a history of multiple sclerosis (MS) and ongoing treatment with glatiramer acetate (GA), immunomodulator. She came to the emergency room due to acute vision changes, and images revealed an enhancing mass in the left pterygopalatine fossa. The diagnosis of AIFS was confirmed by biopsy in the operating room. Subsequently, anti-fungal therapies were initiated with a follow-up operative debridement. Follow-up magnetic resonance imaging (10 months since treatment) showed no progression of AIFS. GA was discontinued since the diagnosis, and MS has remained stable. Recognizing this unique group of atrisk patients is crucial, as early detection and treatment play a pivotal role in preventing significant morbidity and mortality.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A case of acute invasive fungal sinusitis in an immunocompetent patient on glatiramer acetate therapy\",\"authors\":\"Melanie Hicks, J. Bishop, Brenton T. Bicknell, J. Grayson, B. Woodworth, D. Cho\",\"doi\":\"10.23838/pfm.2023.00114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute invasive fungal sinusitis (AIFS) is a rapidly progressing, life-threatening infection. The advent of immunomodulatory therapies has expanded the population susceptible to AIFS. In this case report, we describe a patient who defies the conventional profile of AIFS. This 70-year-old woman is immunocompetent and non-diabetic, with a history of multiple sclerosis (MS) and ongoing treatment with glatiramer acetate (GA), immunomodulator. She came to the emergency room due to acute vision changes, and images revealed an enhancing mass in the left pterygopalatine fossa. The diagnosis of AIFS was confirmed by biopsy in the operating room. Subsequently, anti-fungal therapies were initiated with a follow-up operative debridement. Follow-up magnetic resonance imaging (10 months since treatment) showed no progression of AIFS. GA was discontinued since the diagnosis, and MS has remained stable. Recognizing this unique group of atrisk patients is crucial, as early detection and treatment play a pivotal role in preventing significant morbidity and mortality.\",\"PeriodicalId\":42462,\"journal\":{\"name\":\"Precision and Future Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Precision and Future Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23838/pfm.2023.00114\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Precision and Future Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23838/pfm.2023.00114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

急性侵袭性真菌性鼻窦炎(AIFS)是一种进展迅速、危及生命的感染。免疫调节疗法的出现扩大了 AIFS 的易感人群。在本病例报告中,我们描述了一名与 AIFS 传统特征不同的患者。这位 70 岁的妇女免疫功能正常,无糖尿病,有多发性硬化症(MS)病史,目前正在接受免疫调节剂醋酸格拉替雷(GA)治疗。她因急性视力改变来到急诊室就诊,图像显示左侧翼腭窝有一强化肿块。在手术室通过活检确诊为 AIFS。随后,患者接受了抗真菌治疗,并进行了后续手术清创。随访磁共振成像(治疗后 10 个月)显示 AIFS 没有进展。自确诊以来,GA 已经停用,而 MS 一直保持稳定。认识到这一独特的高危患者群体至关重要,因为早期发现和治疗在预防重大发病率和死亡率方面发挥着关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A case of acute invasive fungal sinusitis in an immunocompetent patient on glatiramer acetate therapy
Acute invasive fungal sinusitis (AIFS) is a rapidly progressing, life-threatening infection. The advent of immunomodulatory therapies has expanded the population susceptible to AIFS. In this case report, we describe a patient who defies the conventional profile of AIFS. This 70-year-old woman is immunocompetent and non-diabetic, with a history of multiple sclerosis (MS) and ongoing treatment with glatiramer acetate (GA), immunomodulator. She came to the emergency room due to acute vision changes, and images revealed an enhancing mass in the left pterygopalatine fossa. The diagnosis of AIFS was confirmed by biopsy in the operating room. Subsequently, anti-fungal therapies were initiated with a follow-up operative debridement. Follow-up magnetic resonance imaging (10 months since treatment) showed no progression of AIFS. GA was discontinued since the diagnosis, and MS has remained stable. Recognizing this unique group of atrisk patients is crucial, as early detection and treatment play a pivotal role in preventing significant morbidity and mortality.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Precision and Future Medicine
Precision and Future Medicine MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
15
审稿时长
10 weeks
期刊最新文献
Survival rate and death risk for associated pulmonary arterial hypertension: A retrospective population-based study Understanding hikikomori syndrome in clinical settings: a case series Development of colistin resistance via heteroresistance modeling in Klebsiella pneumoniae: A diagnostic study Paraneoplastic neurological syndrome associated with onconeural autoantibodies: report of two cases Durable response to first-line treatment with AZD3759 (zorifertinib) in a patient with epithelial growth factor receptor mutated non-small cell lung cancer and untreated multiple brain metastasis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1