脑源性神经营养因子基因 (BDNF) 的 G>A (rs6265) 多态性与白种女性训练后变化的关系

IF 0.7 Q4 SPORT SCIENCES Baltic Journal of Health and Physical Activity Pub Date : 2023-12-31 DOI:10.29359/bjhpa.15.4.03
K. Świtała
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引用次数: 0

摘要

脑源性神经营养因子(BDNF)rs6265(G196A;Val66Met)多态性与肥胖和 2 型糖尿病有关,而风险等位基因为 A 或 G 的结果却相互矛盾。本研究的主要目的是研究 BDNF rs6265 多态性是否会影响训练计划的效率。另外一个目的是确定所选多态性是否可用作肥胖相关参数的遗传标记。我们研究了一组 160 名白种女性的基因型分布情况,在为期 12 周的有氧训练计划前后测量了她们的体重和成分参数、血脂状况和血糖水平。在干预期间,大多数与肥胖相关的参数都发生了显著变化(训练的主效应);但是,训练反应并不受基因型的影响(基因型 × 训练的交互作用不显著)。我们也没有发现基因型对选定参数的影响。我们的研究表明,rs6265 多态性不会影响应用训练计划的效率,也不是评估研究人群肥胖相关参数的良好遗传标记。不过,我们证实,经常进行体育锻炼与肥胖相关参数的改善有关,这对公共卫生来说是一个重要的观察结果。
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Association of the G>A (rs6265) polymorphism in the brain derived neurotrophic factor gene (BDNF) with post-training changes in Caucasian women
The brain-derived neurotrophic factor (BDNF) rs6265 (G196A; Val66Met) polymorphism has been associated with obesity and type 2 diabetes, with contradictory results involving either A or G as the risk allele. The main aim of this study was to examine whether the BDNF rs6265 polymorphism would influence the efficiency of a training program. An additional aim was to determine whether selected polymorphism can be used as a genetic marker for obesity-related parameters. We studied the genotype distribution in a group of 160 Caucasian females in whom body mass and composition parameters, lipid profile, and glucose levels were measured before and after the 12-week aerobic training program. The majority of obesity-related parameters significantly changed during the intervention (main effect of training); however, the training response was not modulated by genotype (non-significant genotype × training interactions). We also did not find an effect of genotype on selected parameters. Our study showed that the rs6265 polymorphism does not affect the efficiency of the applied training program and is not a good genetic marker for assessing the obesity-related parameters in the studied population. However, we confirmed that regular physical activity is associated with an improvement in obesity-related parameters, which is an important observation for public health.
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
17
审稿时长
30 weeks
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