一例多形性真皮肉瘤:内侧鱼尾纹巨型外生瘤

IF 1.6 Q3 DERMATOLOGY Dermatopathology Pub Date : 2023-12-29 DOI:10.3390/dermatopathology11010003
Rylee Moody, Kavita Darji, Tricia A Missall, Peter Chow, R. Behshad
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引用次数: 0

摘要

本病例是一名 99 岁高加索女性的病例,她因左侧内眦长出一个 8.0 厘米 × 7.8 厘米的无痛、外生性、有蒂、溃疡性肿瘤而转诊治疗。病理结果显示,肿瘤细胞呈纺锤形、椭圆形和多角形,细胞核多形性。此外,还发现许多多核巨细胞和有丝分裂。肿瘤突出显示 CD10,肌动蛋白、desmin 和 CD68 呈局灶阳性,免疫组化染色显示 Ki67 增高。肿瘤的泛影角蛋白、CK5/6、p63、MART-1/MelanA、S100、Sox10、p40、CD34 和 CD23 均为阴性。根据临床病理相关性,诊断为多形性真皮肉瘤(PDS)。多形性真皮肉瘤(PDS)是指一种组织学上等级较高的深部肿瘤,在临床和组织学上通常与其他肿瘤相似。由于多形性真皮肉瘤常具有侵袭性,且与不良预后有关,因此必须认识到它与其他类似实体(包括非典型纤维黄瘤(AFX)和多形性细肌瘤(PLMS))的不同之处。据我们所知,文献中仅报道过一例发生在眼部的 PDS。通过回顾和了解特征性病因、发病部位、组织病理学特征和处理技术,病理学家可以做出更准确的诊断,皮肤科医生也可以及时为患者提供更有效的治疗。
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A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus
We present the case of a 99-year-old Caucasian female who was referred for treatment of a painless, 8.0 cm × 7.8 cm exophytic, pedunculated, ulcerated tumor of the left medial canthus. Pathology showed spindled, oval, and polygonal cells with pleomorphic nuclei. Many multinuclear giant cells and mitotic figures were also noted. The tumor was highlighted with CD10, showed focal positivity with actin, desmin, and CD68, and had increased Ki67 immunohistochemical staining. The tumor was negative for pancytokeratin, CK5/6, p63, MART-1/MelanA, S100, Sox10, p40, CD34, and CD23. Based on clinicopathologic correlation, the diagnosis of pleomorphic dermal sarcoma (PDS) was made. Pleomorphic dermal sarcoma (PDS) refers to a deep, histologically high-grade tumor that often resembles other tumors clinically and histologically. As PDS is frequently aggressive and related to adverse outcomes, it is important to recognize its distinguishing features in comparison to other similar entities, including atypical fibroxanthoma (AFX) and pleomorphic leiomyosarcoma (PLMS). To our knowledge, there is only one other reported case in the literature of PDS occurring on the eye. By reviewing and understanding characteristic etiologies, locations of presentation, histopathological features, and management techniques, pathologists can make a more accurate diagnosis and dermatologists can provide more effective patient care in a timely manner.
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来源期刊
Dermatopathology
Dermatopathology DERMATOLOGY-
自引率
5.30%
发文量
39
审稿时长
11 weeks
期刊最新文献
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