pT3 皮肤黑色素瘤侵袭宽度的预后价值

D. Țăpoi, A. Gheorghisan-Galateanu, Laura Maria Gosman, A. Dumitru, A. Ciongariu, Mariana Costache
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摘要

中厚度黑色素瘤的预后受临床和组织病理学特征的影响而变化很大。本研究调查了pT3皮肤黑色素瘤的几个临床病理预后因素,重点关注一个新参数--侵袭宽度。这是一项回顾性研究,研究对象是2012年至2018年期间确诊的49例皮肤黑色素瘤患者,这些患者接受了至少5年的随访。我们评估了年龄、性别、肿瘤位置、布瑞斯洛浸润深度、浸润宽度、有丝分裂指数、有无溃疡、回归、微卫星、淋巴管浸润和神经周围浸润与疾病进展和生存期的关系。Cox 单变量分析显示,无进展生存期(PFS)与年龄、侵袭深度、侵袭宽度、淋巴管侵袭、微卫星和神经周围侵袭显著相关。总生存期(OS)与年龄、浸润深度、浸润宽度、微卫星和神经周围浸润显著相关。通过多变量考克斯比例危险回归,唯一与PFS和OS相关的因素是浸润的宽度。这是为数不多的评估浸润宽度的研究之一,我们证明了这一参数可能成为皮肤黑色素瘤的一个重要预后因素。
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Prognostic Value of the Width of Invasion in pT3 Cutaneous Melanomas
Intermediate-thickness melanomas display highly variable outcomes influenced by both clinical and histopathological characteristics. This study investigates several clinicopathological prognostic factors for pT3 cutaneous melanomas, focusing on a novel parameter, the width of invasion. This is a retrospective study of 49 patients diagnosed with cutaneous melanoma between 2012 and 2018 who were followed up for at least five years. We evaluated the age, gender, tumor location, Breslow depth of invasion, width of invasion, mitotic index, the presence/absence of ulceration, regression, microsatellites, lymphovascular invasion, and perineural invasion for their association with disease progression and survival. Cox univariate analysis revealed that progression-free survival (PFS) was significantly associated with age, depth of invasion, width of invasion, lymphovascular invasion, microsatellites, and perineural invasion. Overall survival (OS) was significantly associated with age, depth of invasion, width of invasion, microsatellites, and perineural invasion. Through multivariate Cox proportional hazards regression, the only factor associated with both PFS and OS was the width of the invasion. This is one of the few studies to assess the width of invasion and we have demonstrated that this parameter could become an important prognostic factor for cutaneous melanomas.
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