无精子症患者睾丸活检的组织学模式:单一机构的经验

Q4 Pharmacology, Toxicology and Pharmaceutics Acta Marisiensis - Seria Medica Pub Date : 2023-12-01 DOI:10.2478/amma-2023-0038
Nina Čamdžić, V. Muzika, S. Čustović, M. Babić, Mirsad Dorić, Edina Lazović Salčin, Suada Kuskunović-Vlahovljak
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摘要

摘要 本研究旨在确定无精症患者睾丸活检标本的组织病理学模式及其发生频率,并根据改良约翰森评分系统进行分类。研究方法研究对象包括临床诊断为无精症的男性患者的睾丸活检样本。所有组织样本均在缓冲 10%福尔马林中固定,进行常规处理并用苏木精和伊红染色。对所有病例进行显微镜检查,并根据组织病理学模式和改良约翰森评分系统进行分类。结果共对 125 例无精症男性患者的 219 例睾丸活检进行了评估,其中 94 例为双侧睾丸活检。最常见的年龄组为 30-39 岁(66.2%)。最常见的组织学模式是仅有 Sertoli 细胞综合征(58.4%),而最少见的模式是生殖细胞成熟停滞,仅占 4.6%。最常见的改良约翰森评分为 2(66.7%)。在进行双侧睾丸活检的患者中,12.76%的患者双侧睾丸的组织学模式不一致。结论我们的研究揭示了无精症患者最常见的组织病理学模式,并强调了对该病症进行更好的国家统计和流行病学研究的必要性。研究还指出了双侧睾丸活检作为诊断和治疗程序的重要性。
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Histological patterns of testicular biopsy in patients with azoospermia: single-institution experience
Abstract Objective of this study was to identify the histopathological patterns and their frequency in testicular biopsy specimens from azoospermic patients and to categorize it according to Modified Johnsen scoring system. Methods: Testicular biopsies from male patients with clinical diagnosis of azoospermia were included in this study. All tissue samples were fixed in buffered 10% formalin, routinely processed and stained with Hematoxylin and Eosin. All cases were examined microscopically and categorized according to the histopathological patterns and Modified Johnsen scoring system. Results: Total 219 cases of testicular biopsies from 125 azoospermic male patients were evaluated, with 94 cases of bilateral testicular biopsy. The most prevalent age group was of 30-39 years (66.2%). The most common histological pattern was of Sertoli cell only syndrome (58.4%) while the least represented pattern was germ cell maturation arrest, seen in 4.6% cases. The most common Modified Johnsen score was 2 (66.7%). There was discordance in histologic pattern in both testes in 12.76% of patients who had bilateral testicular biopsy. Conclusion: Our study gives an insight on the most common histopathological patterns of azoospermic patients and emphasizes the need for a better national statistics and epidemiological studies of this entity. It also points out the significance of the bilateral testicular biopsy, as both, diagnostic and therapeutic procedure.
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
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0
审稿时长
24 weeks
期刊最新文献
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