精子过度激活与 CatSper 通道：家养动物的当前认识和未来贡献

IF 2.7 3区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal Science and Technology Pub Date : 2023-11-29 DOI:10.5187/jast.2023.e133

Jae Yeon Hwang

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引用次数: 0

摘要

在雌性道中，哺乳动物的精子会出现超活化运动，这是精子 18 受精卵的关键生理事件。这种运动变化是由精子特异性 Ca 2+ 通道 19 CatSper 的 Ca 2+ 流入触发的。尽管之前在人类和小鼠身上进行的研究在很大程度上帮助人们了解了 CatSper 和 Ca 2+ 信号对精子过度激活的作用 20，但对它们激活机制的差异 21 还不甚了解。有几项研究探讨了 CatSper 通道在非人和非小鼠模型（如家畜）中的表达和意义。在这篇综述中，我总结了以往研究中有关 CatSper 通道的关键知识 23，并提出了未来利用精子研究 CatSper 的方面。

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Sperm hyperactivation and the CatSper channel: Current understanding and future contribution of domestic animals

In female tract, mammalian sperm develop hyperactivated motility which is a key physiological event for 18 sperm to fertilize eggs. This motility change is triggered by Ca 2+ influx via the sperm-specific Ca 2+ channel, 19 CatSper. Although previous studies in human and mice largely contributed to understanding CatSper and 20 Ca 2+ signaling for sperm hyperactivation, the differences on their activation mechanisms are not well 21 understood yet. There are several studies to examine expression and significance of the CatSper channel in 22 non-human and non-mouse models, such as domestic animals. In this review, I summarize key knowledge 23 for the CatSper channel from previous studies and propose future aspects for CatSper study using sperm

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来源期刊

Journal of Animal Science and Technology Agricultural and Biological Sciences-Food Science

CiteScore

4.50

自引率

8.70%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Animal Science and Technology (J. Anim. Sci. Technol. or JAST) is a peer-reviewed, open access journal publishing original research, review articles and notes in all fields of animal science. Topics covered by the journal include: genetics and breeding, physiology, nutrition of monogastric animals, nutrition of ruminants, animal products (milk, meat, eggs and their by-products) and their processing, grasslands and roughages, livestock environment, animal biotechnology, animal behavior and welfare. Articles generally report research involving beef cattle, dairy cattle, pigs, companion animals, goats, horses, and sheep. However, studies involving other farm animals, aquatic and wildlife species, and laboratory animal species that address fundamental questions related to livestock and companion animal biology will also be considered for publication. The Journal of Animal Science and Technology (J. Anim. Technol. or JAST) has been the official journal of The Korean Society of Animal Science and Technology (KSAST) since 2000, formerly known as The Korean Journal of Animal Sciences (launched in 1956).